- Novel synthesis of thianinhydrin
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The synthesis of the previously reported thianinhydrin (12) was achieved from 3-methylthiophene via the corresponding 5,6-dihydrocyclopenta[b]thiophen-4,6-dione (10). Conversion of 10 to the tricarbonyl (12) proceeded in good yield using dimethydioxirane oxidation of 5,6-dihydro-5-dimethyl aminomethylenecyclopenta[b]thiophen-4,6-dione (14). The fluorescence intensity of the zinc salt of the product of 12 and glycine was similar to that obtained from the product of ninhydrin and the same amino acid.
- Hauze, Diane B.,Joullie, Madeleine M.,Ramotowski, Robert,Cantu, Antonio
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- As hepatitis c inhibitor spiro compound and its use in medicine
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The invention provides a spiro compound serving as a hepatitis c inhibitor and application thereof in a medicine. The compound is a compound as shown in a formula (I) or a stereisomer, a geometric isomer, a tautomer, nitric oxide, an aquo-complex, a solvate, a metabolite, pharmaceutically acceptable salt or prodrug of the compound as shown in the formula (I). The invention also provides a pharmaceutical composition containing the compound, application of the compound and the pharmaceutical composition in inhibition of HCV (Hepatitis C Virus) copy and HCV virus protein, as well as the application of the compound and the pharmaceutical composition in prevention, handling, treatment or relieving of HCV infection or hepatitis c disease for a patient. The formula I is as shown in the specification.
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Paragraph 0760; 0771; 0772
(2017/12/28)
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- SPIRO RING COMPOUND AS HEPATITIS C VIRUS (HCV) INHIBITOR AND USES THEREOF FIELD OF THE INVENTION
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A compound of formula (I) or a stereoisomer, a geometric isomer. a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof is provided, which can be used for treating HCV infection or a HCV disorder. Also a pharmaceutical composition comprising the compound and the use of the compound and the pharmaceutical composition thereof are provided, which can also be used for treating HCV infection or a HCV disorder.
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Page/Page column 210; 211; 212
(2014/06/23)
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- REDUCTION DES CONTRAINTES STERIQUES (EMPECHEMENT A LA CONJUGAISON) DANS LES POLY(DIALKYL-3,4-THIOPHENES)
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Cyclopenta thiophene, cyclopenta thiophene and thieno thiophene have been synthesized.The electropolymerization of these monomers was attempt.The electrical properties of poly(cyclopenta thiophene) are intermediate between those of poly(3-methylthiophene) and poly(3,4-dimethyl thiophene).
- Garreau, R.,Roncali, J.,Garnier, F.,Lemaire, M.
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