A novel class of antibiotics that interfere with lipoprotein targeting have been identified. A high gene copy suppression method is used to identify new compounds. Novel compositions containing the antimicrobials are disclosed as well as their uses.
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(2008/06/13)
Structure-activity relationship study of the bacterial actin-like protein MreB inhibitors: Effects of substitution of benzyl group in S-benzylisothiourea
We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl 2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.