- Through space interaction between ferrocenes mediated by a thioether
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A series of conformationally constrained 2,6-bisferrocenylphenyl thioethers were synthesized via Suzuki-Miyaura cross coupling reactions. Structural information was obtained using X-ray crystallography and dynamic 1H NMR spectroscopic studies,
- Meyer, G. Joel,Hall, Gabriel B.,Smith, Elliott R.,Sakamoto, Takahiro,Lichtenberger, Dennis L.,Glass, Richard S.
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p. 125 - 132
(2015/07/01)
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- Efficient synthesis of rigid ladder polymers via palladium catalyzed annulation
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We report a new method to synthesize rigid ladder polymers using efficient palladium catalyzed annulation reactions with low catalyst loading (1 mol %). Rigid ladder polymers with benzocyclobutene backbone linkages can be synthesized from copolymerization of readily accessible aryl dibromides and norbornadiene or polymerization of AB type monomers bearing norbornene and aryl bromide or triflate moieties. High molecular weight (10-40 kDa) rigid ladder polymers can be obtained with complete monomer conversions. Diverse monomers also gave different, fixed ladder polymer conformations. The ladder polymers exhibited excellent thermal stability, high carbonization yield, and large intrinsic porosity.
- Liu, Sheng,Jin, Zexin,Teo, Yew Chin,Xia, Yan
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p. 17434 - 17437
(2015/02/05)
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- Dual Pharmacophores - PDE4-Muscarinic Antagonistics
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The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use as dual chromaphores having inhibitory activity against PDE4 and muscarinic acetylcholine receptors (mAChRs), and thus being useful for treating respiratory diseases.
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Page/Page column 49
(2009/08/18)
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- Dual Pharmacophores - PDE4-Muscarinic Antagonistics
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The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of/and or prophylaxis of respiratory diseases, including antiinflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.
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Page/Page column 51
(2009/08/16)
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- Poly(thiaheterohelicene): A stiff conjugated helical polymer comprised of fused benzothiophene rings
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(Chemical Equation Presented) A novel helical aromatic polymer comprised of fused benzothiophene rings, poly(thiaheterohelicene), was synthesized via an intramolecular ring-closing reaction with a controlled helicity to one-sided bias. The synthetic helic
- Iwasaki, Tomokazu,Kohinata, Yusaku,Nishide, Hiroyuki
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p. 755 - 758
(2007/10/03)
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