A novel synthetic method of pheniramine maleate is provided. The method includes subjecting benzylboronic acid and 2-halogenpyridine to a condensation reaction to obtain 2-benzylpyridine, subjecting the 2-benzylpyridine and 2-dimethylaminoethyl halide hydrochloride to a substitution reaction to prepare pheniramine, and salifying the pheniramine with maleic acid to obtain the pheniramine maleate. The method is simple in process, high in yield, low in cost and easy in industrial production.