Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents
A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts. Taylor & Francis Group, LLC.
Samadi, Abdelouahid,Silva, Daniel,Chioua, Mourad,Carreiras, Maria Do Carmo,Marco-Contelles, Jose