- Study on the synthesis, antioxidant properties, and self-assembly of carotenoid–flavonoid conjugates
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Flavonoids and carotenoids possess beneficial physiological effects, such as high antioxidant capacity, anticarcinogenic, immunomodulatory, and anti-inflammatory properties, as well as protective effects against UV light. The covalent coupling of hydropho
- Línzembold, Ildikó,Czett, Dalma,B?ddi, Katalin,Kurtán, Tibor,Király, Sándor Balázs,Gulyás-Fekete, Gergely,Takátsy, Anikó,Lóránd, Tamás,Deli, József,Agócs, Attila,Nagy, Veronika
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- Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75
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HIV integrase (IN) is an essential enzyme for the viral replication. Currently, three IN inhibitors have been approved for treating HIV-1 infection. All three drugs selectively inhibit the strand transfer reaction by chelating a divalent metal ion in the
- Li, Bo-Wen,Zhang, Feng-Hua,Serrao, Erik,Chen, Huan,Sanchez, Tino W.,Yang, Liu-Meng,Neamati, Nouri,Zheng, Yong-Tang,Wang, Hui,Long, Ya-Qiu
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p. 3146 - 3158
(2014/06/09)
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- Facile synthesis of flavonoid 7-O-glycosides
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Highly regioselective removal of the 7-O-acyl groups of the peracylated flavones, isoflavones, and flavonols (PhSH, imidazole, NMP) followed by effective glycosylation with glycosyl trifluoroacetimidates (BF 3·Et2O) and cautious deprotection of the acyl groups under basic conditions afforded the desired 7-O-flavonoid glycosides in satisfactory yields.
- Li, Ming,Han, Xiuwen,Yu, Biao
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p. 6842 - 6845
(2007/10/03)
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- Synthesis and hypoglycemic effect of chrysin derivatives
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A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetic mice in spite of the fact that chrysin itself had inhibited insulin release by 40-60%. None of the test animals died at the maximum dose 500mg/kg and did not cause any significant change in general feature, water and food consumption, body weight and organ weight when we examined the acute oral toxicity of those compounds having significant hypoglycemic effect.
- Shin, Joon-Su,Kim, Kyoung-Soon,Kim, Myoung-Bohm,Jeong, Jae-Hoon,Kim, Bak-Kwang
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p. 869 - 874
(2007/10/03)
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- Enzyme-catalyzed alcoholysis of flavone acetates in organic solvent
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Pseudomonas sp. lipase suspended in tetrahydrofuran was used to deacylate flavone acetates. Regioselectivity of the reaction has been observed.
- Natoli, Mariapina,Nicolosi, Giovanni,Piattelli, Mario
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p. 7371 - 7374
(2007/10/02)
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