- Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution
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Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.
- Holmberg-Douglas, Natalie,Nicewicz, David A.
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p. 7114 - 7118
(2019/09/07)
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- Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy
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Introducing an aryl moiety to our previous pyrrolidone scaffold by molecule fusing strategy afforded two sets of isopropylether-pyrrolidone and α-phenylethylamine-pyrrolidone derivatives. Two novel compounds 8b and 8g of the latter serial showed potent p5
- Li, Jin,Wu, Yuelin,Guo, Zizhao,Zhuang, Chunlin,Yao, Jianzhong,Dong, Guoqiang,Yu, Zhiliang,Min, Xiao,Wang, Shengzheng,Liu, Yang,Wu, Shanchao,Zhu, Shiping,Sheng, Chunquan,Miao, Zhenyuan,Zhang, Wannian
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supporting information
p. 2648 - 2650
(2014/06/09)
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- Arthropodicidal pyrazolines, pyrazolidines and hydrazines
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Arthropodicidal pyrazoline, pyrazolidine and hydrazine compounds, including all their geometric and stereoisomers, agriculturally suitable salts thereof and compositions containing them; and a method for controlling arthropods employing said compounds which are: STR1 wherein Q, X, X1, Y and G are as defined in the text.
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- Arthropodicidal tetrahydrobenzopyranopyrazoles
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This invention concerns substituted tetrahydro-benzopyranopyrazoles of the formula wherein R1 to R5 are substituents, or R1, R2 and R5 may independently be hydrogen; intermediates thereto, agricultural compositions containing the tetrahydro-benzopyranopyrazoles and a method for using them to control arthropods in agronomic and nonagronomic environments. Also disclosed is a process for preparing the tetrahydrobenzopyranopyrazoles by cyclization of phosphorus-containing starting reactants in the presence of a halogenating agent and base.
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