- PYRIDAZINONES AS PARP7 INHIBITORS
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The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.
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Paragraph 2072
(2019/11/11)
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- PYRIMIDINE-SUBSTITUTED PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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The invention relates to new pyrrolidine derivatives of the formula (I), wherein R1 to R3, Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceu
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Page/Page column 90
(2014/11/11)
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- PYRIMIDINE-SUBSTITUTED PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R3, Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical
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Paragraph 0366; 0371
(2014/10/29)
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- AZETIDINE DERIVATIVES
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Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.
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Paragraph 0652
(2013/06/28)
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- NEW AZIRIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS
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The invention relates to new azetidine derivatives of the formula (I) wherein Ar1, Ar2, X, R, T and L are as defined in the description, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
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Page/Page column 103
(2013/07/05)
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- The Synthesis of Some Lipophilic Tetradentate Ligands for Use in the Formation of Metal-Linked Polymers
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Two lipophilic tetradentate ligands, 5,5'-di-t-butyl- and 5,5'-dihexyl-2,2'-bipyrimidine, were prepared via either Ullmann or nickel(0)-promoted reactions in low but useful yields.Approaches towards the synthesis of lipophilic ligands based on 2,2'-biimidazole, namely 4,4',5,5'-tetrabutyl-2,2'-biimidazole (from decane-4,5-dione) and various 4,4',5,5'-tetra(arylamino)-2,2'-biimidazoles (from 4,4',5,5'-tetrabromo-2,2'-biimidazole and arylamines), and a 2,2'-bibenzimidazole, 5,5',6,6'-tetra(octyloxy)-2,2'-bibenzimidazole (from N,N'-bisoxamide), were uniformly unsuccessful for preparing the 2,2'-biheteroaryl compounds.
- Crossley, Maxwell J.,Gorjian, Sargon,Sternhell, Sever,Tansey, Kerrie M.
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p. 723 - 738
(2007/10/02)
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