cas 13337-66-1, 7-chloroquinoline-4-carboxylic acid

Articles about 13337-66-1Total 5 be found

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Lutz et al.
p. 1260,1263
(1947)
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AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.
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(2017/12/29)

NOVEL FAP INHIBITORS
The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.
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Paragraph 0365; 0422; 0443

(2014/12/09)

Selective inhibitors of fibroblast activation protein (FAP) with a (4-quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold
Fibroblast activation protein (FAP) is a serine protease that is generally accepted to play an important role in tumor growth and other diseases involving tissue remodeling. Currently there are no FAP inhibitors with reported selectivity toward both the closely related dipeptidyl peptidases (DPPs) and prolyl oligopeptidase (PREP). We present the discovery of a new class of FAP inhibitors with a N-(4-quinolinoyl)-Gly-(2-cyanopyrrolidine) scaffold. We have explored the effects of substituting the quinoline ring and varying the position of its sp2 hybridized nitrogen atom. The most promising inhibitors combined low nanomolar FAP inhibition and high selectivity indices (>10 3) with respect to both the DPPs and PREP. Preliminary experiments on a representative inhibitor demonstrate that plasma stability, kinetic solubility, and log D of this class of compounds can be expected to be satisfactory.
Jansen, Koen,Heirbaut, Leen,Cheng, Jonathan D.,Joossens, Jurgen,Ryabtsova, Oxana,Cos, Paul,Maes, Louis,Lambeir, Anne-Marie,De Meester, Ingrid,Augustyns, Koen,Van Der Veken, Pieter
supporting information
p. 491 - 496
(2013/07/19)

NOVEL FAP INHIBITORS
The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.
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Page/Page column 58

(2013/07/31)

QUINOLYL AMIDE DERIVATIVES AS CCR-5 ANTAGONISTS
The present invention relates to a series of compounds which are CCR-5 receptor antagonists of the general formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.
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Page 31

(2010/02/10)

Chemical Properties

Melting Point: 281-282 °C
Boiling Point: 382.1 °C at 760 mmHg
Flash Point:184.9 °C
Density: 1.469 g/cm³
Vapor Pressure: 1.6E-06mmHg at 25°C
Refractive Index: 1.69
PKA: 0.75±0.10(Predicted)
PSA: 50.19000
LogP: 2.58640

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13337-66-1

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Chemical Properties

Melting Point: 281-282 °C

Boiling Point: 382.1 °C at 760 mmHg

Flash Point:184.9 °C

Density: 1.469 g/cm³

Vapor Pressure: 1.6E-06mmHg at 25°C

Refractive Index: 1.69

PKA: 0.75±0.10(Predicted)

PSA: 50.19000

LogP: 2.58640

Global suppliers and manufacturers of 13337-66-1total 38 suppliers on LookChem

Article Database

13337-66-1

Articles about 13337-66-1Total 5 be found

More Articles about upstream products of 13337-66-1

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Chemical Properties

Melting Point: 281-282 °C

Boiling Point: 382.1 °C at 760 mmHg

Flash Point:184.9 °C

Density: 1.469 g/cm3

Vapor Pressure: 1.6E-06mmHg at 25°C

Refractive Index: 1.69

PKA: 0.75±0.10(Predicted)

PSA: 50.19000

LogP: 2.58640

Global suppliers and manufacturers of 13337-66-1total 38 suppliers on LookChem

Density: 1.469 g/cm³