DEGRADATION OF RAPAMYCIN: RETRIEVAL OF MAJOR INTACT SUBUNITS.
The degradation of rapamycin has made available key substructures which have defined the structures of advanced synthetic intermediates.
Yohannes, Daniel,Danishefsky, Samuel J.
p. 7469 - 7472
(2007/10/02)
On the Remarkable Propensity for Carbon-Carbon Bond Cleavage Reactions in the C8-C10 Region of FK-506
It has been deduced from a series of transformations that formation of a tetrahedral intermediate at C9 in FK-506 occasions fragmentation of the C9-C10 bond by a retro-Claisen-like pathway or the C9-C8 bond by a benzilic acid type rearrangement.Reduction
Fisher, Matthew J.,Chow, Ken,Villalobos, Anabella,Danishefsky, Samuel J.
p. 2900 - 2907
(2007/10/02)
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