- A new inorganic–organic nanohybrid based on a copper(II) semicarbazone complex and the PMo12O403?polyanion: Synthesis, characterization, crystal structure and photocatalytic activity for degradation of cationic dyes
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A new inorganic–organic nanohybrid based on a Keggin-type polyoxomolybdate and a copper(II) semicarbazone complex, namely [Cu2(HL)2(PMo12O40)(OCH3)2(Cl)(H2O)]·8CH3OH·4H2O [HL = pyridine-2-carbaldehyde semicarbazone] (1) was synthesized by a sonochemical method. Single crystals of 1 were synthesized with the branched tube method. The nanohybrid 1 was characterized using FT-IR, PXRD, FESEM, TEM, EDX, UV–Vis, TG-DTA analysis and single-crystal X-ray diffraction. Single-crystal X-ray diffraction reveals that the PMo12O403?cluster acts as a bidentate inorganic ligand and coordinates two symmetrically equivalent [Cu(Cl)0.5(HL)(OCH3)(H2O)0.5] complexes. SEM and TEM images confirmed a highly porous plate-like morphology of the nanohybrid sample. To the best of our knowledge, 1 represents the first example of a hybrid based on POMs and semicarbazone Schiff base complexes. The photocatalytic properties of the nanohybrid 1 were investigated in detail and the results of the photocatalytic experiments show it can be used as an efficient and recoverable photocatalyst for the complete degradation of the cationic dyes methylene blue (MB) and rhodamin B (RhB).
- Farhadi, Saeed,Mahmoudi, Farzaneh,Dusek, Michal,Eigner, Vaclav,Kucerakova, Monika
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- Two coordination polymers based on semicarbazone Schiff base and azide: Synthesis, crystal structure, electrochemistry, magnetic properties and biological activity
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[Mn(L)(μ1,1-N3)2]2n[Mn(H2O) 2(μ1,1-N3)2]n (1) and [Cd(HL)(μ1,1-N3) 2]n (2) have been synthesized from HL (HL: pyridine-2-carbaldehyde semicarbazone) and azide ligands,
- Shaabani, Behrouz,Akbar Khandar, Ali,Dusek, Michal,Pojarova, Michaela,Mahmoudi, Farzaneh,Feher, Alexander,Kajnakova, Marcela
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- A new nanohybrid material constructed from Keggin-type polyoxometalate and Cd(II) semicarbazone Schiff base complex with excellent adsorption properties for the removal of cationic dye pollutants
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A novel nanohybrid material containing a Cd(II) semicarbazone Schiff base complex and phosphomolybdic acid, [Cd(H2L+)6][H2L]+4[PMo12O40]4·18CH3OH
- Farhadi, Saeed,Amini, Mostafa M.,Dusek, Michal,Kucerakova, Monika,Mahmoudi, Farzaneh
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- Anion modulated structural variations in copper(II) complexes with a semicarbazone Schiff base: Synthesis, characterization and self assembly
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Two copper(II) complexes, [Cu(L)N3]n (1) and [Cu(HL)2](I3)ClO4 (2), where HL = 2-pyridylaldehydesemicarbazone, have been prepared and characterized by elemental analysis, IR and UV-Vis spectroscopy and single crystal X-ray diffraction studies. Complex 1 crystallizes in monoclinic space group P2 1/a, whereas, complex 2 crystallizes in triclinic space group P-1. Complex 1 is a stair-like coordination polymer with square pyramidal geometry of copper(II), whereas, complex 2 is a mononuclear cationic bis-ligand complex of octahedral copper(II). Lower coordination ability of tri-iodide or perchlorate compared to azide may be related with variations of the structures of the complexes.
- Das, Mithun,Ghosh, Biswa Nath,Rissanen, Kari,Chattopadhyay, Shouvik
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- Synthesis, crystal structure, antimicrobial activity and electrochemistry study of chromium(III) and copper(II) complexes based on semicarbazone Schiff base and azide ligands
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A tridentate NNO donor Schiff base ligand HL [HL: C5H 4NCH=NNHCONH2] was obtained by condensation of pyridine 2-carbaldehyde with semicarbazide. The HL and azide ligands with Cr(III) and Cu(II) ions have been used to synth
- Shaabani,Khandar,Dusek,Pojarova,Mahmoudi
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- Ultrapotent Inhibitor of Clostridioides difficile Growth, Which Suppresses Recurrence in Vivo
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Clostridioides difficile is the leading cause of healthcare-associated infection in the U.S. and considered an urgent threat by the Centers for Disease Control and Prevention (CDC). Only two antibiotics, vancomycin and fidaxomicin, are FDA-approved for the treatment of C. difficile infection (CDI), but these therapies still suffer from high treatment failure and recurrence. Therefore, new chemical entities to treat CDI are needed. Trifluoromethylthio-containing N-(1,3,4-oxadiazol-2-yl)benzamides displayed very potent activities [sub-μg/mL minimum inhibitory concentration (MIC) values] against Gram-positive bacteria. Here, we report remarkable antibacterial activity enhancement via halogen substitutions, which afforded new anti-C. difficile agents with ultrapotent activities [MICs as low as 0.003 μg/mL (0.007 μM)] that surpassed the activity of vancomycin against C. difficile clinical isolates. The most promising compound in the series, HSGN-218, is nontoxic to mammalian colon cells and is gut-restrictive. In addition, HSGN-218 protected mice from CDI recurrence. Not only does this work provide a potential clinical lead for the development of C. difficile therapeutics but also highlights dramatic drug potency enhancement via halogen substitution.
- Naclerio, George A.,Abutaleb, Nader S.,Li, Daoyi,Seleem, Mohamed N.,Sintim, Herman O.
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p. 11934 - 11944
(2020/11/26)
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- Synthesis, characterization and biological activities of semicarbazones and their copper complexes
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Substituted semicarbazones/thiosemicarbazones and their copper complexes have been prepared and several single crystal structures examined. The copper complexes of these semicarbazone/thiosemicarbazones were prepared and several crystal structures examined. The single crystal X-ray structure of the pyridyl-substituted semicarbazone showed two types of copper complexes, a monomer and a dimer. We also found that the p-nitrophenyl semicarbazone formed a conventional ‘magic lantern’ acetate-bridged dimer. Electron Paramagnetic Resonance (EPR) of several of the copper complexes was consistent with the results of single crystal X-ray crystallography. The EPR spectra of the p-nitrophenyl semicarbazone copper complex in dimethylsulfoxide (DMSO) showed the presence of two species, confirming the structural information. Since thiosemicarbazones and semicarbazones have been reported to exhibit anticancer activity, we examined the anticancer activity of several of the derivatives reported in the present study and interestingly only the thiosemicarbazone showed activity while the semicarbazones were not active indicating that introduction of sulphur atom alters the biological profile of these thiosemicarbazones.
- Venkatachalam, Taracad K.,Bernhardt, Paul V.,Noble, Chris J.,Fletcher, Nicholas,Pierens, Gregory K.,Thurecht, Kris J.,Reutens, David C.
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p. 295 - 308
(2016/11/12)
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- Synthesis of 2-amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via sequential condensation and I2-mediated oxidative C-O/C-S bond formation
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2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I2-mediated oxidative C-O/C-S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion.
- Niu, Pengfei,Kang, Jinfeng,Tian, Xianhai,Song, Lina,Liu, Hongxu,Wu, Jie,Yu, Wenquan,Chang, Junbiao
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p. 1018 - 1024
(2015/01/30)
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- A green approach for the synthesis of biologically active heterocyclic compounds at the platinum electrode
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In the present study, 2-amino-5-substituted-1,3,4-oxadiazoles (4a-k) have been synthesized by the electrochemical oxidation of semicarbazone (3a-k) using platinum anode at room temperature under controlled potential electrolysis in an undivided cell assem
- Sanjeev, Kumar,Srivastava
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p. 1019 - 1026
(2013/09/23)
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- Synthesis and characterization of new series of imidazolidin-2,4-dione derivatives and its antimicrobial activity
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The synthesis of compound (2) was achieved using cyclization method of compound (1) with ethyl chloro acetate and fused sodium acetate. Compound (2) was underwent mannten reaction to give compound (3a-3f). The Chemical structures were elucidated by IR,su
- Kumar, R. Surendra,Idhayadhulla,Nasser, A. Jamal Abdul,Selvin
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experimental part
p. 1425 - 1430
(2011/10/18)
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- Spectroscopic, thermal and biocidal studies on Mn(II), Co(II), Ni(II) and Cu(II) complexes of tridentate ligand having semicarbazone moieties
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Mn(II), Co(II), Ni(II) and Cu(II) complexes having the general composition M(L)2X2 [where L = 2-pyridinecarboxaldehyde semicarbazone, M = Mn(II), Co(II), Ni(II) and Cu(II), X = Cl- and NO3 -] have been synthesized. All the synthesized compounds were identified and confirmed by elemental analysis, molar conductance, magnetic susceptibility measurements, mass, IR, EPR, electronic spectral studies and thermogravimetric analysis (TG). The Molar conductance measurements of the complexes lie in the range 209-228 Ω1 cm-1 mol -1 indicating that the complexes are 1:2 electrolytic in nature. Thus the complexes may be formulated as [M(L)2]X2. The magnetic moment measurements of the complexes indicate that all the complexes are in high-spin state. On the basis of spectral studies an octahedral geometry has been assigned for Mn(II), Co(II) and Ni(II) complexes whereas tetragonal geometry for Cu(II) complexes. The thermal studies suggested that the complexes are more stable compared with free ligand. This fact was supported by calculating the thermodynamic parameters by using Horowitz-Metzger (HM) and Coats-Redfern (CR) equations. The free ligand and its metal complexes were also evaluated against the growth of phytopathogenic fungi and bacteria in vitro.
- Refat, Moamen S.,Chandra, Sulekh,Tyagi, Monika
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experimental part
p. 261 - 267
(2010/08/05)
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