Highly Regio- and Stereocontrolled Glyoxylate-Ene Reaction with (Homo)Allylic Ethers: Remarkable Alkoxy Effect in Regio- and Stereocontrol
A highly regio- and stereocontrolled glyoxylate-ene reaction with allylic and homoallylic ethers has been developed, which allows regio- and stereospecific multifunctionalizations as highlighted by a short synthesis of (+/-)-avenaciolide.