- Liquid crystal alignment properties on polyamide films bearing a phenylenediacryloyl moiety in the main chain
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Soluble photosensitive polyamide, which has a photoreactive 1,4-phenylenediacryloyl (PDA) moiety in the main chain with biphenyl side groups, was synthesized with high molecular weights. The polymer produced high quality films through conventional spin-ca
- Kwon, Se Jin,Chae, Boknam,Kim, Joo Young,Jung, Woo-Sik,Lee, Seung Woo
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Read Online
- A biphenyl diamine compound and a curing resin compositon comprising the same
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The present invention relates to a liquid crystal display device. A novel biphenyl based diamine compound represented by chemical formula I and a curing agent thereof are provided to improve thermal conductivity and thermal stability. Chemical Formula I. (In the formula, Y is (CH). 2 )n (Integer between n=1 and 10), X is F, CN, CH. 3 O, And CH3 CH2 What is selected at O.
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Paragraph 0043-0046; 0054-0056
(2021/11/02)
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- LINKER-DRUG AND ANTIBODY-DRUG CONJUGATE (ADC) EMPLOYING THE SAME
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A linker-drug represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), C is a conjugator, L is a linker unit, D is a toxin unit, and n is an integer ranging from 1 to 4. The structure of the conjugator is represented by formula (II). In formula (II), X is a leaving group, each of R1 and R2 is independently a single bond or —NH—, and Z is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) employing the above linker-drug is also provided.
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Paragraph 0157-0159
(2018/07/05)
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- Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs
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A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
- Redko, Boris,Albeck, Amnon,Gellerman, Gary
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p. 2188 - 2191
(2013/01/15)
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- ACETYLENE COMPOUND, SALT THEREOF, CONDENSATE THEREOF, AND COMPOSITION THEREOF
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[Problem to be Solved] To provide an acetylene compound having a structure in which a unit having an amino group and a unit having an ethynyl group are bonded via a linking group, the acetylene compound being introducable to a polymer having thermal resis
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Page/Page column 61
(2010/07/08)
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- Non-covalent polyvalent ligands by self-assembly of small glycodendrimers: A novel concept for the inhibition of polyvalent carbohydrate-protein interactions in vitro and in vivo
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Polyvalent carbohydrate-protein interactions occur frequently in biology, particularly in recognition events on cellular membranes. Collectively, they can be much stronger than corresponding monovalent interactions, rendering it difficult to control them with individual small molecules. Artificial macromolecules have been used as polyvalent ligands to inhibit polyvalent processes; however, both reproducible synthesis and appropriate characterization of such complex entities is demanding. Herein, we present an alternative concept avoiding conventional macromolecules. Small glycodendrimers which fulfill single molecule entity criteria self-assemble to form non-covalent nanoparticles. These particles - not the individual molecules - function as polyvalent ligands, efficiently inhibiting polyvalent processes both in vitro and in vivo. The synthesis and characterization of these glycodendrimers is described in detail. Furthermore, we report on the characterization of the non-covalent nanoparticles formed and on their biological evaluation.
- Thoma, Gebhard,Streiff, Markus B.,Katopodis, Andreas G.,Duthaler, Rudolf O.,Voelcker, Nicolas H.,Ehrhardt, Claus,Masson, Christophe
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- Novel hyperbranched polymer based on urea linkages
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The thermal decomposition of 3,5-diaminobenzoyl azide, to generate in situ the corresponding 3,5-diaminophenyl isocyanate, was found to give hyperbranched polyureas, whose structure was established using IR and NMR spectroscopy.
- Kumar, Anil,Meijer
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p. 1629 - 1630
(2007/10/03)
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