- An Efficient Ga(OTf)3/Isopropanol Catalytic System for Direct Reduction of Benzylic Alcohols
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This study aims to report the first gallium-catalyzed direct reduction of benzylic alcohols using isopropanol as a reductant. The reaction proceeds via gallium catalyst-assisted hydride transfer of the in situ-generated benzylic isopropyl ether. The method generates only water and acetone as byproducts and thus provides an atom-economic and environmentally friendly approach to the synthesis of di- and triarylmethanes, which are important substructures in various bioactive compounds and functional materials. (Figure presented.).
- Sai, Masahiro
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supporting information
p. 4330 - 4335
(2018/10/15)
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- Synthetic method of diaryl methanol compound
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The invention discloses a synthetic method of a diaryl methanol compound. Compared with a reported method for obtaining the diaryl methanol compound through catalytic reduction by taking diaryl ketone as an initial raw material, the method is characterized by taking substituted benzyl bromide and substituted phenylboronic acid which are cheap and easy to obtain as initial raw materials, reacting for 4 hours in an alkaline solution, water or a mixed solvent of the water and an organic solvent under room temperature in air, and carrying out simple separation and purification operation, thus obtaining a pure product. A catalyst adopted in the method is a palladium compound/an in-situ catalytic system prepared from phosphorus- and oxygen-containing carboxylic acids ligands, the catalytic system is cheap in price, high in catalytic activity and good in selectivity and is stable in the air and a water solution, the diaryl methanol compound is compounded through a method of catalyzing the substituted benzyl bromide and the substituted phenylboronic acid and a 'one-pot reaction method' of hydrogen peroxide, the reaction steps are less, after-treatment is simple, the product is easy to separate and purify, the yield is high, and the mixed solvent is prepared from cheap and easy-to-obtain water and the organic solvent, so that the environment is not polluted, and environment protection is realized.
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Paragraph 0059-0061
(2017/04/03)
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- Air-stable solid aryl and heteroaryl organozinc pivalates: Syntheses and applications in organic synthesis
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A wide range of air-stable, solid, polyfunctional aryl and heteroarylzinc pivalates were efficiently prepared by either magnesium insertion or Hal/Mg exchange followed by transmetalation with Zn(OPiv)2 (OPiv=pivalate). By reducing the amount of
- Manolikakes, Sophia M.,Ellwart, Mario,Stathakis, Christos I.,Knochel, Paul
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supporting information
p. 12289 - 12297
(2015/03/31)
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