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13404-22-3

Articles about 13404-22-3Total 5 be found

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Cyclic phosphoramidates as prodrugs of 2′-C-methylcytidine
The currently approved treatment for hepatitis C virus infections is a combination of Ribavirin and pegylated Interferon. It leads to a sustained virologic response in approximately only half of the patients treated. For this reason there is an urgent need of new therapeutic agents. 2′-C-Methylcytidine is the first nucleoside inhibitor of the HCV NS5B polymerase that was efficacious in reducing the viral load in patients infected with HCV. The application of a monophosphate prodrug approach based on unprecedented cyclic phosphoramidates is reported. Our SAR studies led to compounds that are efficiently converted to the active triphosphate in human hepatocytes.
Meppen, Malte,Pacini, Barbara,Bazzo, Renzo,Koch, Uwe,Leone, Joseph F.,Koeplinger, Kenneth A.,Rowley, Michael,Altamura, Sergio,Di Marco, Annalise,Fiore, Fabrizio,Giuliano, Claudio,Gonzalez-Paz, Odalys,Laufer, Ralph,Pucci, Vincenzo,Narjes, Frank,Gardelli, Cristina
scheme or table
p. 3765 - 3770
(2009/12/24)

Antiviral phosphoramidates
The invention provides novel nucleoside compounds of formula I wherein R1, R2a, R2b, R3, R4, R5, R6, R8a, R9 and R10 are as defined herein which are useful for the treatment of Hepatitis C Virus (HCV) mediated diseases. The invention further provides methods for treatment or prophylaxis of HCV mediated diseases with compounds of formula I and pharmaceutical compositions comprising these compounds,
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Page/Page column 18

(2008/06/13)

Synthesis of optically active lipopeptide analogs from the outer membrane of Escherichia coli
The synthesis of optically active lipopeptide derivatives has been accomplished by the use of chiral glycerol derivatives. Lipopeptide derivatives with (R)-glycerol moieties showed higher mitogenic activities than those with the (S)-configuration. N-2,2,2-Trichloroethoxycarbonyl lipopeptide derivatives increased mitogenic activity.
Kurimura,Takemoto,Achiwa
p. 2590 - 2596
(2007/10/02)

Derivatives of 2,6-diamino-3-haloheptanedioic acid
This invention relates to amino acid, dipeptide and tripeptide derivatives of 2,6-diamino-3-haloheptanedioic acids, processes for preparing the same, and their use as antibacterial agents.
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(2008/06/13)

Carboxyalkyl amino acid derivatives of various substituted prolines
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(2008/06/13)

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Chemical Properties

Melting Point: 168-175 °C (dec.)
Boiling Point: 163.1 °C at 760 mmHg
Flash Point:37 °C
Solubility:Soluble in methanol.
Storage Temp.:2-8°C
Vapor Pressure: 2.1mmHg at 25°C
Refractive Index: 2.0 ° (C=2, EtOH)
Sensitive: Hygroscopic
BRN: 3562140
PSA: 52.32000
LogP: 2.17760

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