Azaindole-based inhibitors of Cdc7 kinase: Impact of the Pre-DFG residue, Val 195
To investigate the role played by the unique pre-DFG residue Val 195 of Cdc7 kinase on the potency of azaindole-chloropyridines (1), a series of novel analogues with various chloro replacements were synthesized and evaluated for their inhibitory activity
Tong, Yunsong,Stewart, Kent D.,Florjancic, Alan S.,Harlan, John E.,Merta, Philip J.,Przytulinska, Magdalena,Soni, Nirupama,Swinger, Kerren K.,Zhu, Haizhong,Johnson, Eric F.,Shoemaker, Alexander R.,Penning, Thomas D.
supporting information
p. 211 - 215
(2013/03/29)
PYRROLOPYRIDINE INHIBITORS OF KINASES
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
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Page/Page column 43
(2011/10/31)
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