- SIMPLE MANUFACTURING AND PURIFICATION TECHNOLOGY FOR HIGH PURITY PROPOFOL
-
A process for manufacturing Pure Propofol with a purity of more than 99.90% is disclosed, said process comprising dissolving Crude Propofol in a solvent in which it is soluble to form a solution, treating the solution with aqueous alkali to form an aqueous alkali layer and a solvent layer, separating the aqueous alkali layer from the solvent layer using a phase separation technique, distilling off the solvent from the solvent layer, and distilling a residue of the solvent containing Propofol using steam or boiling water in a presence of dilute alkali and antioxidant like metabisulfite, under normal pressure or mild vacuum.
- -
-
Paragraph 0033-0035
(2021/08/14)
-
- Continuous flow synthesis of propofol
-
Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol— also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkylation followed by a decarboxylation step, both under continuous flow.
- Jubault, Philippe,Legros, Julien,Mougeot, Romain,Poisson, Thomas
-
supporting information
(2021/12/02)
-
- PROCESS FOR THE PREPARATION OF PROPOFOL
-
The present provides a simple, convenient and time-efficient process for the preparation of propofol. Particularly, the present invention provides an improved process for the preparation of propofol using a heterocyclic base for the decarboxylation reaction. The present invention provides a time-efficient process for the preparation of propofol with high yield and purity.
- -
-
Page/Page column 10
(2021/10/02)
-
- Preparation method of propofol and structural analogues of propofol
-
The invention relates to a preparation method of propofol and structural analogues of propofol. The preparation method comprises the steps as follows: preparing an intermediate from p-hydroxybenzoic acid and alkyl alcohol as raw materials under the action of a solid acid catalyst, and then preparing a target product by a decarboxylase reaction. The preparation method has the characteristics of being green in synthesis, realizing biotransformation, causing little pollution, producing few by-products and the like, and is suitable for industrial production; the purity of the prepared products such as propofol is 99.6% or higher, which meets various medicinal standards.
- -
-
Paragraph 0092; 0093
(2017/08/28)
-
- PHARMACOLOGICALLY ACTIVE COMPOUNDS
-
The present invention relates to compounds of formula (I) shown below: wherein Q is as defined herein. The compounds of formula (I) act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
- -
-
Paragraph 00135
(2015/07/15)
-
- Commercial manufacturing of propofol: Simplifying the isolation process and control on related substances
-
A commercially viable manufacturing process for propofol (1) is described. The process avoids acid-base neutralization events during isolation of intermediate, 2,6-di-isopropylbenzoic acid (3) and crude propofol, and thus simplifies the synthesis on industrial scale to a considerable extent. Syntheses of five impurities/related substances (USP and EP) are also described.
- Pramanik, Chinmoy,Kotharkar, Sandeep,Patil, Pradip,Gotrane, Dinkar,More, Yogesh,Borhade, Ajit,Chaugule, Balaji,Khaladkar, Tushar,Neelakandan,Chaudhari, Ashok,Kulkarni, Mukund G.,Tripathy, Narendra K.,Gurjar, Mukund K.
-
p. 152 - 156
(2014/05/20)
-
- PHENOL C-ALKYLATION PROCESS
-
A method for obtaining high purity 2, 6-diisopropylphenol comprises alkylating 4- hydroxybenzoic acid in presence of an acid followed by basification and decarboxylating 4- hydroxy-3, 5-diisopropylbenzoic acid in presence of high boiling solvents and a catalyst at high temperature.
- -
-
Page/Page column 5
(2013/03/26)
-
- PROCESS FOR PREPARING EXTRA PURE 2, 6-DIISOPROPYL PHENOL
-
Disclosed herein is a process for the preparation of highly pure 2,6-diisopropyl phenol (Formula I), which comprises reacting p-hydroxy benzoic acid (Formula II) with an alkylating agent in presence of aq. mineral acid followed by basification and subsequent washings to yield 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) free of dimer impurity, 4, 4''-oxydibenzoic acid of Formula IV, ether impurity 3,5-di(propan-2-yl)-4- (propan-2-yloxy)benzoic acid of Formula V and the monoalkylated impurity 4-hydroxy- 3-(propan-2-yl) benzoic acid of Formula VI; and decarboxylating 4- hydroxy-3,5- diisopropylbenzoic acid (Formula III) in presence of high boiling solvent and sodium hydroxide as a catalyst at high temperature to yield 2, 6-diisopropyl phenol substantially free of ether impurity 1,3-di(propan-2-yl)-2-(propan-2-yloxy)benzene of Formula VII and monoalkylated phenol impurity 2-(propan-2-yl) phenol of Formula VIII. Propofol prepared by the process of the present invention is suitable for pharmaceutical use.
- -
-
Page/Page column 8
(2012/01/13)
-
- Long emission wavelength chemiluminescent compounds and their use in test assays
-
An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use in such methods as
- -
-
-
- Nickel salt-ester stabilizing compositions
-
Compositions of nickel salts of 4-hydroxybenzoic acids and esters of aliphatic or aromatic carboxylic acids, which esters have boiling points of at least about 250° C. are useful for stabilizing polyolefins against degradation by heat and ultraviolet radiation and for rendering polyolefins dyeable.
- -
-
-
- Nickel stabilizers and dye enhancers for polyolefins
-
Products of the reaction of about 30 to 90 parts by weight of a compound of formula (I) STR1 wherein R1 and R2 are each alkyl radicals having up to 8 carbon atoms at least one of which is branched on the alpha carbon, and R3 and R4 are each hydrogen or an alkyl radical having up to 18 carbon atoms, and about 70 to 10 parts by weight, respectively, of a secondary or tertiary phosphite are useful for stabilizing polyolefins against degradation by heat and ultraviolet radiation and for rendering polyolefins dyeable by chelatable dyes such as aromatic ortho hydroxy azo dyes.
- -
-
-