- Chirality Transfer from Chiral Monoamines to an m-Phthalic Diamide-Linked Zinc Bisporphyrinate with a Benzylamide Substituent
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An m-phthalic diamide-linked bisporphyrin with a benzylamide substituent has been designed and synthesized. It has two types of carbonyl groups. In the solution of this zinc bisporphyrinate, these carbonyl groups are involved in the formation of two diffe
- Hu, Qingyun,Zhuo, Congcong,Wang, Yong,Hu, Chuanjiang,Lang, Jianping
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Read Online
- Mutual binding of polymer end-groups by complementary π-π-stacking: A molecular "roman Handshake"
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Self-complementary tweezer-molecules based on a naphthalenediimide core self-assemble into supramolecular dimers through mutual π-π-stacking and hydrogen bonding. The resulting motif is extremely stable in solution (K a = 105 M-
- Greenland, Barnaby W.,Bird, Matthew B.,Burattini, Stefano,Cramer, Rainer,O'Reilly, Rachel K.,Patterson, Joseph P.,Hayes, Wayne,Cardin, Christine J.,Colquhoun, Howard M.
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- An amide hydrogen bond templated [1]rotaxane displaying a peptide motif-demonstrating an expedient route to synthetic mimics of lasso peptides
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The rapid synthesis of an amide hydrogen bond templated [1]rotaxane is reported-demonstrating a potential pathway to synthetic analogues of lasso peptides. The structures of the [1]rotaxane and its unthreaded isomer have been characterized by NMR spectros
- Akien, Geoffrey R.,Evans, Nicholas H.,Young, Matthew J.
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Read Online
- Solvent Directed Synthesis of Molecular Cage and Metal Organic Framework of Copper(II) Paddlewheel Cluster
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A solvothermal reaction of a clip-type dicarboxylic acid H2DCA [3,3′-((5-nitroisophthaloyl)bis(azanediyl))-dibenzoic acid] and Cu(NO3)2 in equimolar ratio in dimethylformamide (DMF) yielded MOF(CuCG1) which was formed by i
- Howlader, Prodip,Mukherjee, Partha Sarathi
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Read Online
- Alternative approach to an AB2 monomer for hyperbranched poly(arylene ether ketone imide)s
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An alternative approach to an AB2 monomer, N-[3,5-bis(4-hydroxybenzoyl) benzene]-4-fluorophthalimde, 4, for hyperbranched poly(arylene ether ketone imide)s has been developed. The key steps were a para-position selective electrophilic aromatic substitutio
- Yu, Zhenning,Fossum, Eric,Wang, David H.,Tan, Loon-Seng
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- An expedient approach to internally functionalized chiral dendrimers: Synthesis of a dendritic molecule incorporating furanoside skeleton
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In an approach to chiral dendritic molecules, a dendrimer incorporating pentose units in the interior and hexose units in the periphery is built up on a 1, 3, 5-trisubstituted aromatic core by using 1,2:5,6-diisopropylidene glucose as the carbohydrate precursor and a 3, 5-disubstituted aromatic unit as the branching block. The carbohydrate moiety also provides internal functionalities in the form of hemiacetal moiety of the furanoside ring.
- Ghorai, Subir,Bhattacharjya, Anup,Basak, Ajoy,Mitra, Abhijit,Williamson, R. Thomas
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Read Online
- Convergent Ditopic Receptors Enhance Anion Binding upon Alkali Metal Complexation for Catalyzing the Ritter Reaction
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A supramolecular approach to catalyzing the Ritter reaction by utilizing enhanced anion-binding affinity in the presence of alkali metal cations was developed with ditopic hydrogen-bonded amide macrocycles. With prebound cations in the macrocycle, particu
- Kang, Kang,Nagarajan, Sangaraiah,Chen, Lixi,Deng, Pengchi,Shen, Xin,Fu, Kuirong,Feng, Wen,Yuan, Lihua,Lohrman, Jessica A.,Johnson, Darren W.
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supporting information
p. 652 - 655
(2019/04/10)
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- Azo pigment, a coloring agent for a color filter, a colored composition for color filter
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[A] (heat resistance, light resistance) has excellent durability, less foreign film, not only a good storage stability or dye transfer, high luminance, color composition for color filter of the same color when expressed in the film thickness. [Solution] a
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Paragraph 0182
(2019/07/18)
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- Cationic lipid molecule, and application thereof in nucleic acid delivery
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The present invention discloses a cationic lipid molecule, and an application thereof in nucleic acid delivery. The structural formula of the cationic lipid molecule is represented by formula i. The invention further provides a cationic liposome, a lipid compound, a reagent, a kit, a preparation and a medicinal composition based on the cationic lipid molecule. The cationic lipid molecule has the advantages of simple synthesis process and good stability, and the cationic liposome has a high efficiency (characterized by high transfection efficiency) and a low toxicity, is stable and uniform, is easy to prepare, and can be used for transferring various cell lines. The cationic lipid molecule has excellent transitivity, and can efficiently deliver active substances (such as exemplary siRNA) omto cells (such as exemplary lung cancer cells), tissues and organs to achieve efficient regulation of the active substances. The problem that the toxicity and the transfer efficiency of cationic liposome existing in the prior art are low is solved.
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Paragraph 0114-0117
(2019/10/08)
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- AZO PIGMENT, COLOR FILTER COLORANT, COLORING COMPOSITION, AND COLOR FILTER
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PROBLEM TO BE SOLVED: To provide a color filter coloring composition which is excellent in heat resistance and light resistance, causes few particles in a coating and has good storage stability, and in addition has a high luminance and a high contrast ratio. SOLUTION: An azo pigment comprises a compound represented by a formula (1) in the figure and a monoazo compound not having one of the azo groups in the formula (1). [R1 is a halogen atom, a substituted/unsubstituted alkyl group, or a substituted/unsubstituted alkoxyl group; R2 and R3 are each independently H, a substituted/unsubstituted alkyl group, or a substituted/unsubstituted phenyl group; and X1 to X4 are each independently H, a substituted/unsubstituted alkyl group, a hydroxyl group, a cyano group, a nitro group, a carboxyl group, a sulfo group, or a halogen atom.] SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPOandINPIT
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Paragraph 0191
(2019/12/25)
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- AZO PIGMENT, COLOR FILTER COLORANT, COLORING COMPOSITION, AND COLOR FILTER
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PROBLEM TO BE SOLVED: To provide a color filter coloring composition which is excellent in fastness such as heat resistance and light resistance, causes few particles in a coating and has good storage stability, and in addition has a high luminance and a
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Paragraph 0225
(2020/01/07)
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- COMPOUND, CURED PRODUCT, POLYMER, PHOTO-ALIGNMENT FILM, OPTICALLY ANISOTROPIC BODY AND LIQUID CRYSTAL DISPLAY ELEMENT
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A compound and a polymer which can each form a photo-alignment film having excellent ability of controlling alignment, a photo-alignment film obtained using the polymer and an optically anisotropic body and a liquid crystal display element each having the photo-alignment film are provided. A compound represented by the general formula (1). In the formula, P represents a polymerizable group, Z and Z1 represent divalent linking groups, A and A1 represent divalent cyclic groups, and X1 to X5 each independently represent a hydrogen atom, a fluorine atom, a chlorine atom, a hydroxy group, a nitro group, a cyano group or an alkyl group having 1 to 40 carbon atoms which may have a substituent, provided that X1, X2, X4 and X5 are not simultaneously hydrogen atoms.
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Paragraph 0194
(2018/08/30)
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- Azo pigment, a coloring agent for a color filter, a color filter and a bonding composition
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An object of the present invention is to provide a coloring composition for a color filter which is excellent in not only heat resistance and light resistance, but also has a small amount of foreign matter in a coating film, good storage stability, and hi
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Paragraph 0167
(2018/09/25)
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- Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum
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Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of ferriprotoporphyrin IX (Fe(III)PPIX). Well-developed SAR models exist for β-hematin inhibition, parasite activity, and cellular mechanisms for this compound class, but no comparably detailed investigations exist for other hemozoin inhibiting chemotypes. Here, benzamide analogues based on previous HTS hits have been purchased or synthesized. Only derivatives containing an electron deficient aromatic ring and capable of adopting flat conformations, optimal for π-π interactions with Fe(III)PPIX, inhibited β-hematin formation. The two most potent analogues showed nanomolar parasite activity, with little CQ cross-resistance, low cytotoxicity, and high in vitro microsomal stability. Selected analogues inhibited hemozoin formation in Plasmodium falciparum causing high levels of free heme. In contrast to quinolines, introduction of amine side chains did not lead to benzamide accumulation in the parasite. These data reveal complex relationships between heme binding, free heme levels, cellular accumulation, and in vitro activity of potential novel antimalarials.
- Wicht, Kathryn J.,Combrinck, Jill M.,Smith, Peter J.,Hunter, Roger,Egan, Timothy J.
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p. 6512 - 6530
(2016/07/23)
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- Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality
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1:1 and 2:2 oligomeric piperazinophanes with an intraannular ester functionality have been synthesized via Mannich reaction of various aromatic esters with piperazine by a one-pot reaction under benign conditions through the multicomponent reaction methodology. The newly synthesized piperazinophanes were characterized using spectral and analytical methods. The ester based 1:1 oligomeric piperazinophanes exhibit good target binding ability in molecular docking studies and also show better antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyogenes bacteria than the 2:2 oligomeric piperazinophanes.
- Selvarani, Sivasamy,Rajakumar, Perumal
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p. 9494 - 9499
(2016/11/11)
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- Linker-Region Modified Derivatives of the Deoxyhypusine Synthase Inhibitor CNI-1493 Suppress HIV-1 Replication
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The inhibition of cellular factors that are involved in viral replication may be an important alternative to the commonly used strategy of targeting viral enzymes. The guanylhydrazone CNI-1493, a potent inhibitor of the deoxyhypusine synthase (DHS), preve
- Schr?der, Marcus,Kolodzik, Adrian,Windshügel, Bj?rn,Krepstakies, Marcel,Priyadarshini, Poornima,Hartjen, Philip,Van Lunzen, Jan,Rarey, Matthias,Hauber, Joachim,Meier, Chris
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- THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
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Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
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(2015/02/19)
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- THERAPEUTICALLY ACTIVE COMPOUNDS AND USE THEREOF
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Provided are therapeutically active compounds and the use in manufacture of medicaments for treating a cancer characterized by the presence of a mutant allele of IDH1.
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(2015/02/19)
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- THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
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Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
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Page/Page column 138
(2015/02/19)
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- SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
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The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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Paragraph 0861
(2015/06/10)
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- PIGMENT DISPERSANT, AND PIGMENT COMPOSITION, COLORING COMPOSITION AND COLOR FILTER USING THE SAME
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PROBLEM TO BE SOLVED: To provide a pigment dispersant that exhibits an extremely good characteristic in enhancing the dispersibility of pigment, to provide a pigment composition, produced by using the pigment dispersant, that is excellent in the contrast
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Paragraph 0206; 0207
(2016/11/09)
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- The pigment composition, a colored composition, color filter
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PROBLEM TO BE SOLVED: To provide a pigment composition that is excellent, when used for a color filter, in its contrast ratio and luminance, has a good heat resistance and light stability, and does not generate a coated film foreign body, as well as to pr
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Paragraph 0173
(2016/11/14)
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- Neutral redox-active hydrogen- and halogen-bonding [2]rotaxanes for the electrochemical sensing of chloride
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The first examples of redox-active ferrocene-functionalised neutral [2]rotaxanes have been synthesised via chloride anion templation. 1H NMR spectroscopic titrations reveal that these [2]rotaxane host systems recognize chloride selectively over other halides and oxoanions in highly-competitive aqueous media. By replacing the hydrogen bonding prototriazole units of the rotaxane axle component with iodotriazole halogen bond-donor groups, the degree of chloride selectivity of the [2]rotaxanes is modulated. Electrochemical voltammetric experiments demonstrate that the rotaxanes can sense chloride via cathodic perturbations of the respective rotaxanes' ferrocene-ferrocenium redox-couple upon anion addition.
- Lim, Jason Y. C.,Cunningham, Matthew J.,Davis, Jason J.,Beer, Paul D.
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supporting information
p. 17274 - 17282
(2015/01/08)
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- Enantioselective hydrophosphination of enones with diphenylphosphine catalyzed by bis(imidazoline) NCN pincer palladium(II) complexes
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A series of chiral NCN pincer Pd(II) complexes with 1,3-bis(2′- imidazolinyl)phenyl (Phebim) ligands were synthesized via the C-H activation or oxidative addition method. A dinuclear macrocyclic Pd(II) complex was also prepared by reaction of the Phebim-H
- Hao, Xin-Qi,Zhao, Yong-Wei,Yang, Jing-Jing,Niu, Jun-Long,Gong, Jun-Fang,Song, Mao-Ping
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supporting information
p. 1801 - 1811
(2014/05/06)
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- SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
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Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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(2014/12/12)
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- Formation constants in C-H hydrogen bonding. 4. Effects of cyano, nitro, and trifluoromethyl substituents in aromatic compounds
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Formation constants ( Keq) have been measured using 1H NMR for H-bond complexes with HMPA in CCl 4of 35 aromatic compounds variously substituted with cyano, nitro, and trifluoromethyl groups; several compounds contained F and Cl. The three strongly polar groups enhance H-bonding significantly, usually in the order NO2 > CN > CF3; all are superior to Cl and F. 1,3,5-Trinitrobenzene fails to H-bond at all; however, TNT, its tert-butyl analog, and trinitro-m-xylene show significant Keq values. Coplanarity of nitro groups with the ring blocks approach of HMPA, probably via intramolecular H-bonds. The buttressing effect is evident in some crowded compounds.
- Lorand, John P.
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p. 186 - 205
(2015/02/19)
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- Controllable self-assembly of amphiphilic macrocycles into closed-shell and open-shell vesicles, nanotubes, and fibers
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Depending on functional groups, amphiphilic hexaamide macrocycles self-assemble into closed-shell and open-shell vesicles in polar solvents. In the presence of water, open-shell vesicles morph into closed-shell vesicles, whereas acidification of the mediu
- Mitra, Atanu,Panda, Dillip K.,Corson, Lucas J.,Saha, Sourav
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supporting information
p. 4601 - 4603
(2013/06/05)
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- THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
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Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
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(2013/07/31)
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- THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
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Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
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Page/Page column 137; 138
(2013/07/31)
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- Increased halide recognition strength by enhanced intercomponent preorganisation in triazolium containing [2]rotaxanes
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Three triazolium-based [2]rotaxanes containing different sized axle and macrocycle components were synthesised in good yields (40-57 %) through chloride anion templation. The anion recognition properties of the interlocked receptor systems were investigat
- White, Nicholas G.,Costa, Paulo J.,Carvalho, Silvia,Felix, Vitor,Beer, Paul D.
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p. 17751 - 17765
(2014/01/17)
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- Room temperature columnar liquid crystalline phases of luminescent non-symmetric star-shaped molecules containing two 1,3,4-oxadiazole units
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In the present work, we show the synthesis and full characterization of 12 new 1,3,4-oxadiazole non-symmetrical star-shaped molecules containing amide or imine connecting groups, variable number and positions of linear or branched alkoxy chains and differ
- Westphal, Eduard,Prehm, Marko,Bechtold, Ivan H.,Tschierske, Carsten,Gallardo, Hugo
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p. 8011 - 8022
(2014/01/06)
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- Investigating the effect of macrocycle size in anion templated imidazolium-based interpenetrated and interlocked assemblies
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The effect of varying the size of the macrocycle component on the formation of anion templated imidazolium interpenetrated assemblies is investigated. Two different approaches to reducing the macrocycle size are undertaken and the stabilities of the resul
- Spence, Graeme T.,White, Nicholas G.,Beer, Paul D.
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experimental part
p. 7282 - 7291
(2012/10/08)
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- Synthesis and photophysical properties of 2,6-dicyano-p-phenylenediamine
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The photophysical and electrochemical properties of p-phenylenediamine (PPD) are strongly affected by the addition of cyano groups to the aromatic ring. In 2,3,5,6-tetracyano-p-phenylenediamine (TCPPD) the photophysics is governed mostly by the solvent basicity (β) whereas in 2,6-dicyano-N,N, N′,N′-tetramethyl-p-phenylenediamine (DCTMPPD) by the solvent polarity/polarizability (π*). In order to study the interactions of cyano-substituted PPDs with the solvent molecules in more detail as well as to clarify the role and origin of hydrogen bonding differences for TCPPD and DCTMPPD, another cyano substituted PPD, 2,6-dicyano-p-phenylenediamine (DCPPD) has been synthesized. The photophysical properties have been measured in a wide range of solvents. The fluorescence lifetimes (from 14 ns to 20 ns) and quantum yields (from 0.7 to 0.85) are not very sensitive to the environment. The solvatochromism is analyzed by a linear solvation energy relationship (LSER) using parameters developed by Kamlet, Taft and co-workers. It has been found that both absorption and emission of DCPPD depend on specific as well as non-specific interactions of the solute with the solvent molecules. The ground and excited state pKa values for DCPPD have also been determined.
- Zahid, Muhammad,Rosspeintner, Arnulf,Angulo, Gonzalo,Grampp, Günter,Jacques, Patrice,Mansha, Asim
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experimental part
p. 54 - 63
(2012/02/01)
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- Novel interfacially-polymerized polyamide thin-film composite membranes: Studies on characterization, pervaporation, and positron annihilation spectroscopy
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To improve the pervaporation performance of thin-film composite membranes, novel thin-film composite membranes were prepared via interfacial polymerization by reacting 5-nitrobenzene-1,3-dioyl dichloride (NTAC) or 5-tert-butylbenzene- 1,3-dioyl dichloride
- Chao, Wei-Chi,Huang, Shu-Hsien,An, Quanfu,Liaw, Der-Jang,Huang, Ying-Chi,Lee, Kueir-Rarn,Lai, Juin-Yih
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experimental part
p. 2414 - 2421
(2012/03/10)
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- Determination of binding constants of hydrogen-bonded complexes by ITC, NMR CIS, and NMR diffusion experiments
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The host-guest complex formation between barbital and various acylaminopyridyl isophthalamides (Hamilton receptors) has been determined quantitatively. The syntheses of nine isophthalamides are described. Their structures differ in the substitution patter
- Dethlefs, Christiane,Eckelmann, Jens,Kobarg, Hauke,Weyrich, Thomas,Brammer, Stefan,Naether, Christian,Luening, Ulrich
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body text
p. 2066 - 2074
(2011/05/16)
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- Covalent reinforcement of hydrogen-bonded discs into stably folded helical structures
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The presence of covalent tethers significantly enhanced the stability of structures consisting of helically arranged benzenetricarboxamide units that otherwise undergo very weak hydrogen-bonding interaction. The resultant molecular structures were probed
- Chen, Zhongzhu,Urban, Nathaniel D.,Gao, Yi,Zhang, Wenrui,Deng, Jingen,Zhu, Jin,Zeng, Xiao Cheng,Gong, Bing
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supporting information; experimental part
p. 4008 - 4011
(2011/10/02)
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- Columnar mesomorphism of bent-rod mesogens containing 1,2,4-oxadiazole rings
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In this study, the synthesis, characterization, and mesomorphic properties of ten new bent-rod compounds containing two units of 1,2,4-oxadiazoles are reported. In order to understand the relationship between the structure and the mesomorphic behavior, molecules containing a variety of polar substituents (i.e., I, NO2, NH2, OH) on the central rigid core were prepared. The hexagonal columnar mesomorphism was characterized by DSC and POM and the nature of the mesophases was established through XRD studies. The driving force for self-assembly can be explained by microsegregation between the aliphatic parts and the polar parts, producing a dimer, trimer, and tetramer inside a single disc.
- Gallardo, Hugo,Ferreira, Marli,Vieira, André A.,Westphal, Eduard,Molin, Fernando,Eccher, Juliana,Bechtold, Ivan H.
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experimental part
p. 9491 - 9499
(2011/12/15)
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- SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS
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Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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Page/Page column 54-55
(2010/11/03)
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- AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents
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Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the p
- Gugliotta, Giuseppe,Botta, Mauro,Tei, Lorenzo
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scheme or table
p. 4569 - 4574
(2010/12/18)
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- Protein surface recognition by dendritic ruthenium(II) tris(bipyridine) complexes
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We report protein surface binding of dendritic ruthenium(II) tris(bipyiridine) complexes to α-chymotrypsin, resulting in a 1:1 and 1:2 protein complex formation as well as inhibition of the enzyme activity. The Royal Society of Chemistry 2009.
- Ohkanda, Junko,Satoh, Ritsuko,Kato, Nobuo
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supporting information; experimental part
p. 6949 - 6951
(2010/04/25)
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- A novel synthesis of chiral guanidinium receptors and their use in unfolding the energetics of enantiorecognition of chiral carboxylates
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(Chemical Equation Presented) A novel synthetic route to the versatile chiral bicyclic guanidinium building block is described making use of L-methionine as a starting material from the natural chiral pool. Furthermore, the synthetic elaboration of this building block is shown in the construction of macrocyclic and open chain hosts, respectively. The host design employs urea functions as the connecting units and supplementary anchor groups for the complexation of anions. The binding studies of these hosts with various chiral and achiral oxoanions are performed by isothermal titration calorimetry. A trend analysis of the binding energetics in an ensemble of structurally similar guests discloses the importance of geometrical confinement of the guest. Association entropy rather than free energy (affinity) is identified as an indicator of structural uniqueness needed to distinguish configurational isomers in the recognition of enantiomeric carboxylates by the chiral guanidinium hosts.
- Jadhav, Vinod D.,Schmidtchen, Franz P.
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p. 1077 - 1087
(2008/09/18)
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- 5-Substituted isophthalamides as insulin receptor sensitizers
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A novel series of 5-substituted isophthalamides and their structure-activity relationship as insulin receptor sensitizers is discussed.
- Robinson, Louise,Bajjalieh, Sonia,Cairns, Nicholas,Lum, Robert T.,Macsata, Robert W.,Manchem, Vara Prasad,Park, Sophia J.,Rao, Sandhya,Schow, Steven R.,Shi, Songyuan,Spevak, Wayne R.
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scheme or table
p. 3492 - 3494
(2009/04/04)
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- Cooperative and ion-pair recognition by heteroditopic calix[4]diquinone receptors
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A new family of heteroditopic calix[4]diquinone receptors capable of the cooperative recognition of ion-pair species through a contact binding mechanism has been developed. The receptors bind contact ion pairs cooperatively, with an unprecedented AND recognition phenomenon being observed to operate in certain cases, in which receptors display no affinity for either of the individual "free" cation or anion, but bind the cation and anion ion-pair strongly. X-ray crystallographic, solution-state, and computational methods rationalize the observed recognition behavior of the receptors. It is shown that the contact ion-pair interaction occurs through a π-stacking-mediated folding of the receptors such that the anion and cation binding sites are arranged in close proximity, while in the solid state an unusual ion-mediated receptor dimerization is observed. Molecular dynamics simulations are further used to explain the observed trends in the association constants of different ion-pair species and the mechanism of interaction.
- Lankshear, Michael D.,Dudley, Ian M.,Chan, Kar-Man,Cowley, Andrew R.,Santos, Sergio M.,Felix, Vitor,Beer, Paul D.
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supporting information; experimental part
p. 2248 - 2263
(2009/04/06)
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- Self-organization of dendritic supermolecules, based on isocyanide-gold(I), -copper(I), -palladium(II), and -platinum(II) complexes, into micellar cubic mesophases
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First- and second-generation dendrimers with an isocyanide group as the focal functional point (CN-Gn; n: 1,2) and their corresponding organometallic complexes [MCl(CN-Gn)] (M: Au, Cu), [{CuCl(CN-G n)2}2/s
- Coco, Silverio,Cordovilla, Carlos,Donnio, Bertrand,Espinet, Pablo,Garcia-Casas, Maria Jesus,Guillon, Daniel
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experimental part
p. 3544 - 3552
(2009/05/07)
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- 5-Substituted isophthalate-based organic electrochromic materials
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A new series of isophthalate-based electrochromic materials were prepared. The functional groups at the 5-position of isophthalate have a significant influence on the observed color. In particular, an electrochemically active nitro group induced a multi-color display, indicating that further electrochromic properties could be manipulated using more diverse 5-substituted isophthalate derivatives. The Royal Society of Chemistry 2008.
- Sharmoukh,Ko, Kyoung Chul,Ko, Ju Hong,Nam, Hye Jin,Jung, Duk-Young,Noh, Changho,Lee, Jin Yong,Son, Seung Uk
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experimental part
p. 4408 - 4413
(2010/03/24)
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- Versatile and practical macrocyclic reagent with multiple hydrogen-bonding sites for chiral discrimination in NMR
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Bifunctional macrocycles 1-4 and diamide 5 were designed and synthesized. NMR studies demonstrated that, among them, receptor 1 functions as the best chiral solvating agent (shift reagent), which is effective for a wide range of chiral compounds having a carboxylic acid, oxazolidinone, carbonate, lactone, alcohol, sulfoxide, sulfoximine, sulfinamide, isocyanate, or epoxide functionality. The addition of only 5 mol % (69 μg, 0.15 mM) of 1 splits the enantiomeric signals of sulfoxide 13. The excellent performance of 1 as a chiral solvating agent, such as versatility, signal sharpness, high splitting ability, high sensitivity, wide detection window, and synthetic accessibility, is reported. NMR studies revealed that the principal binding site of 1 is the two amide NH groups of the lower segment and that the additional binding site is the pyridyl nitrogen. The V-shaped arrangement of the two 2,6-diacylaminopyridine moieties as constructed in 1 was found to be much more effective for binding a variety of compounds than the parallel alignment of the two binding motifs as constructed in 4. The NO2 group in 1 enhanced not only the binding ability but also the degree of enantioselectivity. Unexpectedly, the comparisons between 1 and 3 enabled us to find the importance of the relative orientation of the binaphthyl moiety; the orthogonal disposition of the binaphthyl moiety in 1 most effectively brings about the differential ring-current effect on the chiral guest molecule bound, which leads to the high degree of chiral discrimination in NMR.
- Ema, Tadashi,Tanida, Daisuke,Sakai, Takashi
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p. 10591 - 10596
(2008/02/13)
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- Versatile and practical chiral shift reagent with hydrogen-bond donor/acceptor sites in a macrocyclic cavity
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Bifunctional macrocycle 1 with C2 symmetry was newly synthesized. NMR studies demonstrated that receptor 1 functions as a chiral shift reagent (solvating agent) that is highly effective for a wide range of chiral compounds having a carboxylic a
- Ema, Tadashi,Tanida, Daisuke,Sakai, Takashi
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p. 3773 - 3775
(2007/10/03)
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- Judging on host-guest binding mode uniqueness: Association entropy as an indicator in enantioselection
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Supramolecular enantiodifferentiation was studied by isothermal titration calorimetry in an effort to address the order-disorder distinction in the diastereomeric complexes formed from a chiral macrocyclic host and enantiomeric carboxylates. As a result,
- Jadhav, Vinod D.,Schmidtchen, Franz P.
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p. 2329 - 2332
(2007/10/03)
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- Iron binding dendrimers: A novel approach for the treatment of haemochromatosis
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A range of iron binding dendrimers terminated with hexadentate ligands formed from hydroxypyridinone, hydroxypyranone, and catechol moieties have been synthesized in order to investigate their potential as clinically useful iron(III)-selective chelators capable of removing dietary iron from the gastrointestinal tract and preventing the development of iron overload typical of haemochromatosis and thalassaemia intermedia. The iron chelating abilities of these molecules have been characterized by MALDI-TOF mass spectrometry and UV spectrometry. Hydroxypyridinone-terminated dendrimers were found to possess a high affinity and selectivity for iron(III). A hydroxypyridinone-based dendrimer was demonstrated to be highly efficient at reducing the absorption of iron(III) in rat intestine. This family of dendrimers may find an application in the treatment of iron overload.
- Zhou, Tao,Neubert, Hendrik,Liu, Ding Yong,Liu, Zu Dong,Ma, Yong Min,Kong, Xiao Le,Luo, Wei,Mark, Sykes,Hider, Robert C.
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p. 4171 - 4182
(2007/10/03)
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- 4-substituted-phenyl(bisoxazoline)-rhodium complexes: Efficiency in the catalytic asymmetric reductive aldol reaction
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Electronic effects of the substituents on the phenyl ring of the phenyl(bisoxazoline) ligand skeleton of rhodium catalysts was examined in the asymmetric reductive aldol reactions of acrylates and aldehydes. The electron-withdrawing NO2 group o
- Shiomi, Takushi,Ito, Jun-Ichi,Yamamoto, Yoshihiko,Nishiyama, Hisao
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p. 5594 - 5600
(2008/02/04)
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- Water-induced fluorescence quenching of mono- and dicyanoanilines
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Photophysical properties of monocyano- (2-, 3-, and 4-cyano) and dicyano- (3,4-, 3,5-, 2,3-, 2,4-, 2,5-, and 2,6-dicyano) anilines are investigated by fluorescence measurements. All the monocyanoanilines are virtually nonfluorescent in water (quantum yield 0.01); however, in nonaqueous solvents (cyclohexane, acetonitrile and ethanol), the fluorescence quantum yield is enhanced substantially. In contrast, dicyanoanilines investigated are highly fluorescent both in aqueous and nonaqueous environments. The photophysical data and MO calculations suggest that conformational changes in the amino group and variation of hydrogen-bonding interactions between the solute and solvent water upon electronic excitation are responsible for the water quenching in the monocyanoanilines.
- Oshima, Juro,Yoshihara, Toshitada,Tobita, Seiji
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p. 306 - 311
(2008/02/13)
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