The present invention provides compounds of formula (I), (II) or (III) wherein R1and R11are boronic acid or a borate ester useful for detection of hydrogen peroxide and methods of using same.
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(2013/03/26)
Luciferin Derivatives from Bicyclic Reactants and Aminothiol Derivatives and Methods of Use Thereof
The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
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Paragraph 0417
(2013/11/06)
Compounds and Methods for Detecting Reactive Oxygen Species
The present disclosure provides compounds that detect reactive oxygen species in a living cell, in a multicellular organism, or in a cell-free sample. The compounds find use in a variety of applications, which are also provided. The present disclosure provides compositions comprising a subject compound.
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(2013/12/04)
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