- Phosphine-free palladium catalytic system for the selective direct arylation of furans or thiophenes bearing alkenes and inhibition of heck-type reaction
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Palladium acetate associated to potassium carbonate as catalytic system has been found to efficiently catalyse the direct 5-arylation of furans or thiophenes bearing enal, enone or acrylate functions at carbon C-2, and to inhibit the Heck-type reaction. The nature of the base is crucial to control the selectivity of the arylation. In the presence of electron-deficient aryl bromides and potassium carbonate as the base, the direct arylation is favoured, whereas the use of potassium fluoride gave selectively the Heck-type product, and tri-n-butylamine the reductive addition product. Copyright
- Chen, Lu,Roger, Julien,Bruneau, Christian,Dixneuf, Pierre H.,Doucet, Henri
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supporting information; experimental part
p. 2749 - 2760
(2011/12/02)
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