- General, stereoselective synthesis of (Z)-β,γ-unsaturated nitriles promoted by samarium diiodide
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(Chemical Equation Presented) A method to obtain (Z)-β,γ- unsaturated nitriles in high or good yields and with moderate or high stereoselectivity is described. The products were achieved through the photoinduced metalation of 3-acetoxy-4-chloronitriles with Sml2. The starting compounds were readily prepared, and a mechanism is proposed to explain this stereoselective β-elimination reaction.
- Concellon, Jose M.,Rodriguez-Solla, Humberto,Simal, Carmen,Santos, David,Paz, Nieves R.
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supporting information; scheme or table
p. 4549 - 4552
(2009/05/11)
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- Ketone precursors for organoleptic compounds
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The invention discloses ketones of formula I: wherein, Y is an optionally substituted alkyl, cycloalkyl, or cycloalkylalkyl, wherein each alkyl group is straight or branched and each alkyl and cycloalkyl group is saturated or unsaturated; R1is hydrogen or a C1-6alkyl group that is substituted, saturated or unsaturated, straight or branched; A is a chromophoric substituted aromatic ring or ring system; n is an integer; and with the proviso that formula I is not 2-ethoxy-1-phenyl-ethanone. These compositions are useful for the delivery of organoleptic compounds, especially of flavors, fragrances, masking agents and antimicrobial compounds.
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