The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase
The guanidine function in the potent neuraminidase inhibitor peramivir was included early on in the drug design process, and examination of X-ray structural data for the enzyme-inhibitor complex would seem to indicate that the guanidine plays a critical r
Bromba, Caleb M.,Mason, Jeremy W.,Brant, Michael G.,Chan, Tracy,Lunke, Martine D.,Petric, Martin,Boulanger, Martin J.,Wulff, Jeremy E.
p. 7137 - 7141
(2012/01/13)
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