Synthesis and biological evaluation of 1,3,4-oxadiazoles bearing amino acid moiety
In the present investigation a series of N-{[5-(4-substituted phenyl)-1,3,4-oxadiazol-2-yl] substituted} benzamide derivatives were synthesized by esterification of 4-substituted aromatic acids followed by hydrazinolysis of esters with hydrazine hydrate to get 4-substituted acid hydrazides. The NH2 group of amino acid was protected using benzoyl chloride. The final step involves the cyclization of acid hydrazides and N-protected amino acid using POCI3 to yield the corresponding N-{[5-(4-substituted phenyl)-1,3,4-oxadiazol-2-yl] substituted} benzamide derivatives. The synthesized compounds were evaluated for antibacterial and antifungal activity. All compounds showed good activity compared to the standard drugs.
Sankar,Ramajayam
p. 41 - 44
(2013/09/24)
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