From ring to ring: The first total synthesis of (+)-daphmanidinE features rapid access to an enantiomerically pure bicyclo[2.2.2]octadione and elaboration around its periphery through the implementation of two Claisen rearrangements, the use of a copper/peptide complex for reagent-controlled stereoselective conjugate addition, a diastereoselective hydroboration, and a cobalt-catalyzed alkyl-Heck cyclization.
Weiss, Matthias E.,Carreira, Erick M.
p. 11501 - 11505
(2012/01/12)
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