- Regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridines by Suzuki-Miyaura and Sonogashira cross-coupling reactions
-
An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridine was developed. This sequence allowed the selective introduction of aryl, heteroaryl, alkyl and alkynyl substituents at both 2- and 3-positions, by using Suzu
- Delaye,Pénichon,Allouchi,Enguehard-Gueiffier,Gueiffier
-
-
Read Online
- An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via silver(I)-catalyzed C-H bond functionalization
-
Abstract: An efficient and economic Ag-catalyzed method for the direct cross-coupling of unactivated imidazo[1,2-a]pyridines with arylboronic acids has been developed. This approach leads to the formation of corresponding 2,3-diarylimidazo[1,2-a]pyridine derivatives as biological and pharmaceutical materials of interest in good yields under mild reaction conditions. Graphical abstract: [Figure not available: see fulltext.].
- Khoshneviszadeh, Mehdi,Soheilizad, Mehdi,Fardpour, Maryam,Mahdavi, Mohammad
-
p. 1817 - 1821
(2017/09/26)
-
- Efficient access to 2,3-diarylimidazo[1,2-a ]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation
-
An expeditious one-pot, ligand-free, Pd(OAc)2-catalyzed, three-component reaction for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines was developed under microwave irradiation. With the high availability of commercial reagents and great efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines analogues.
- Wang, Yuanxiang,Frett, Brendan,Li, Hong-Yu
-
supporting information
p. 3016 - 3019
(2014/06/23)
-
- An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence
-
An efficient method to prepare 2,3-diarylimidazo[1,2-a]pyridines is described. The procedure involves a Suzuki cross-coupling reaction followed by a direct arylation at position 3. Imidazo[1,2-a]pyridin-2-yl triflate was identified as a suitable coupling partner, permitting access to a variety of highly functionalized 2,3-diarylimidazo[1,2-a]pyridines.
- Marhadour, Sophie,Bazin, Marc-Antoine,Marchand, Pascal
-
p. 297 - 300
(2012/01/31)
-
- Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
-
A novel series of 2,3-diarylimidazo[1,2-a]pyridines was synthesized and evaluated for their antileishmanial activities. Four derivatives exhibited good activity against the promastigote and intracellular amastigote stages of Leishmania major, coupled with a low cytotoxicity against the HeLa human cell line. The impact of compound lipophilicity on antiparasitic activities was investigated by Log D comparison. Although LmCK1 could be the parasitic target for three compounds (13, 18, 21), the inhibition of another target is under study to explain the antileishmanial effect of the most promising compounds.
- Marhadour, Sophie,Marchand, Pascal,Pagniez, Fabrice,Bazin, Marc-Antoine,Picot, Carine,Lozach, Olivier,Ruchaud, Sandrine,Antoine, Maud,Meijer, Laurent,Rachidi, Najma,Le Pape, Patrice
-
p. 543 - 556
(2013/02/23)
-