FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS
The present invention relates to novel functionally selective ligands of dopamine D2 receptors, including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.
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Page/Page column 51
(2012/01/15)
Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D2 receptor agonists
Functionally selective G protein-coupled receptor (GPCR) ligands, which differentially modulate canonical and noncanonical signaling, are extremely useful for elucidating key signal transduction pathways essential for both the therapeutic actions and side
Chen, Xin,Sassano, Maria F.,Zheng, Lianyou,Setola, Vincent,Chen, Meng,Bai, Xu,Frye, Stephen V.,Wetsel, William C.,Roth, Bryan L.,Jin, Jian
p. 7141 - 7153
(2012/11/07)
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