Derivatives of Phenylurea as Antagonists of Mice, Rat, Guinea Pig, and Rabbit 5-HT3 Receptors
1,2,4-Oxadiazolyl- and O-alkyloximinomethyl-substituted phenylureas equipotently bind to 5-HT3 receptors from different species in vitro in contrast to the normal 10-100 fold lower affinity for guinea pig ileal receptors. Compared to the in vitro receptor
Hansen, John Bondo,Christensen, Birgitte,Weiss, Jan,Suzdak, Peter D.,Sheardown, Malcolm J.,et al.
p. 308 - 315
(2007/10/03)
Substituted urea compounds and their preparation and use
New substituted urea compounds of formula I, or a pharmaceutically acceptable salt thereof: STR1 wherein R1 is a group of formula II, III or IV STR2 where n is 2 or 3, p is 1 or 2, q is 1 to 3, r is 1-3 and R4 and R5 are H
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(2008/06/13)
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