- Acat inhibitors for treating hypocholesterolemia
-
The present invention are novel amino acid amide compounds of the following general formula which inhibit the enzyme acylcoenzyme A:cholesterol acyltransferase: STR1 wherein R is phenyl or 1- or 2-naphthyl which are unsubstituted or may be substituted; R1 is hydrogen or a straight or branched alkyl group having from 1 to 6 carbon atoms; R2 is hydrogen, an aliphatic group, an aromatic group, an aralkyl or diarylalkyl group or R1 and R2 form a carbocyclic group; R3 is hydrogen, an aliphatic group, an aralkyl group wherein the alkyl moiety may contain a carbocyclic entity; R4 is hydrogen, an aliphatic group, SO2 R14, --C(=S)NHR15, --CO2 R15, --COR18, or --C(=O)NHR15 wherein R14 is morpholino, phenyl or substituted phenyl; R15 is an alkyl group, phenyl or phenylalkyl wherein the phenyl group may be substituted; and R18 is the same is R15 or is halo-substituted alkyl, 9-fluoroenylmethylene or pyrrolidino.
- -
-
-