COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
This invention relates to a compound of Formula 1A: or a pharmaceutically acceptable salt thereof: wherein R1 to R4. R7, R9 to R12 and Y are as defined herein. The invention further relates to pharmaceutical composition comprising said compound or a pharm
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Page/Page column 29-32
(2012/08/07)
Inhibitors of aminoglycoside resistance activated in cells
The most common mechanism of resistance to aminoglycoside antibiotics entails bacterial expression of drug-metabolizing enzymes, such as the clinically widespread aminoglycoside N-6′-acetyltransferase (AAC(6′)). Aminoglycoside-CoA bisubstrates are highly
Vong, Kenward,Tam, Ingrid S.,Yan, Xuxu,Auclair, Karine
experimental part
p. 470 - 475
(2012/06/18)
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