- Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents
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The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity.
- Rai, Ganesha,Thomas, Craig J.,Leister, William,Maloney, David J.
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scheme or table
p. 1710 - 1713
(2009/07/05)
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- Pharmacochemistry of the furoxan ring: Recent developments
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In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.
- Calvino,Di Stilo,Fruttero,Gasco,Sorba,Gasco
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p. 321 - 334
(2007/10/02)
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- Unsymmetrically Substituted Furoxans, XIII. Phenylfuroxancarbaldehydes and Related Compounds
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The synthesis and structure of two isomeric phenylfuroxancarbaldehydes 7a and 7b, of the phenylfurazancarbaldehyde 6 and of the corresponding alcohols 3a, 3b and 5 are reported.Thermal equilibration of the furoxan derivatives and their oxidation to the co
- Gasco, Andrea Marcello,Fruttero, Roberta,Sorba, Giovanni,Gasco, Alberto
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p. 1211 - 1213
(2007/10/02)
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