- Regioselective sulfonylation at O-2 of cyclomaltoheptaose with 1-(p-tolylsulfonyl)-(1H)-1,2,4-triazole
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2I-O-p-Tolylsulfonylcyclomaltoheptaose was obtained in 42% yield by reaction of 1-(p-tolylsulfonyl)-(1H)-1,2,4-triazole on NaH-deprotonated cyclomaltoheptaose in DMF and further converted into the corresponding mono-2I,3I-
- Law, Ho,Baussanne, Isabelle,Garcia Fernandez, Jose M.,Defaye, Jacques
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Read Online
- Synthesis of sulfonamides from azoles and sodium sulfinates at ambient temperature
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NBS or NIS mediated direct S[sbnd]N bond formation between azoles and sodium sulfinates is described. The reaction shows good substrate scope and tolerates a wide range of functionalities in both azoles and sodium sulfinate substrates. Pyrazoles are also suitable for this method, various 4-halopyrazoles derivatives were obtained by using N-halosuccinimide (NXS) as the halogen source.
- Fu, Lili,Bao, Xiaodong,Li, Shanshan,Wang, Lingtian,Liu, Zhiguo,Chen, Wanzhi,Xia, Qinqin,Liang, Guang
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p. 2504 - 2511
(2017/04/03)
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- Highly efficient preparation of amides from aminium carboxylates using N-(p-toluenesulfonyl) imidazole
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Treatment of aminium carboxylates with N-(p-toluenesulfonyl)imidazole in the presence of triethylamine in DMF at 100 °C afforded the corresponding amides in good to excellent yields. N-(p-Toluenesulfonyl)imidazole proved to be a highly efficient coupling reagent for the preparation of numerous structurally diverse primary, secondary and tertiary amides.
- Behrouz, Somayeh,Rad, Mohammad Navid Soltani,Forouhari, Elham
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p. 101 - 106
(2016/03/08)
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- Organic small molecular fluorescent probe for detecting methanol and preparation method of organic small molecular fluorescent probe
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The invention discloses a preparation method of an organic small molecular fluorescent probe for detecting methanol. The preparation method comprises the following steps: firstly, preparing 1-(p-toluenesulfonyl) imidazole; secondly, preparing the organic small molecular fluorescent probe: adding a proper amount of 4-bromotriphenylamine and the 1-(p-toluenesulfonyl) imidazole into a tetrahydrofuran solution, and then adding a catalyst consisting of copper sulfate pentahydrate and sodium ascorbate into the solution; protecting by nitrogen and stirring for 12 hours, extracting with dichloromethane, drying by using anhydrous magnesium sulfate, and performing rotary evaporation to obtain a crude product; performing column chromatographic separation on the crude product by using ethyl acetate and petroleum ether, wherein the volume ratio of the ethyl acetate to the petroleum ether is 1 to (10 to 20), and separating to obtain a solid, namely the organic small molecular fluorescent probe for detecting the methanol. The fluorescent probe disclosed by the invention has a high fluorescent selective response to the methanol; the fluorescence intensity is remarkably enhanced along with the prolonging of time; the organic small molecular fluorescent probe has the advantages of easiness in preparation, good chemical stability, high sensitivity and the like.
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Paragraph 0017; 0019; 0020
(2017/10/14)
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- Iodine-catalyzed expeditious synthesis of sulfonamides from sulfonyl hydrazides and amines
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A new synthesis of sulfonamides has been developed via an iodine-catalyzed sulfonylation of amines with arylsulfonyl hydrazides. This metal-free strategy employs readily accessible and easy to handle starting materials, catalysts and oxidants, and can be easily conducted under mild conditions, providing a convenient access to a wide range of sulfonamides in moderate to excellent yields within a short reaction time.
- Yotphan, Sirilata,Sumunnee, Ladawan,Beukeaw, Danupat,Buathongjan, Chonchanok,Reutrakul, Vichai
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p. 590 - 597
(2016/01/12)
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- One-step conversion of azine N -oxides to α-1,2,4-triazolo-, 1,2,3-triazolo, imidazolo-, and pyrazoloheteroarenes
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Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides were converted to their α-triazole and α-diazole derivatives by treatment with the corresponding p-toluenesulfonylazoles and Hunigs base at elevated temperatures.
- Keith, John M.
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supporting information; experimental part
p. 2722 - 2725
(2010/07/17)
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- PROCESS FOR MAKING ANASTROZOLE
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A process for making anastrozole using a 1-substituted triazole can reduce formation of the undesired iso-anastrozole. A typical process is represented by wherein compound (10) is a 1-substituted triazole and compound (1) is anastrozole.
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Page/Page column 3-5
(2010/11/30)
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- Adaptation of Staphylococcus aureus to synthetic triazolides
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The ability of Staphylococcus aureus to adapt to the toxic action of 1,2,4-triazole and its sulfuryl derivates has been studied. A positive correlation is found between the lipophilicity and toxicity of substances. It is established that methylated deriva
- Selezneva,Belousova,Ivanchina,Ten'gaev
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p. 145 - 148
(2007/10/03)
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- Pharmaceutical use of N-Carbamoylazole derivatives
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The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent comprising a compound represented by the general formula (I):
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- Synthesis of the sulfonylpyrimidine derivatives as a new type of sulfonylcycloureas
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The synthesis of several novel N-1 and N-1,NH-4-disulfonylpyrimidine derivatives are described.
- Kasnar, Biserka,Krizmanic, Irena,Zinic, Mladen
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p. 1067 - 1071
(2007/10/03)
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- A CONVENIENT SYNTHESIS OF PHOSPHORUS AND SULFONYL-SUBSTITUTED N-IMIDAZOLES (TRIAZOLES) USING THE CORRESPONDING ACID CHLORIDES AND N-TRIMETHYLSILYL IMIDAZOLES (TRIAZOLES)
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The synthetic route phosphorus and sulfonyl-substituted N-imidazoles (triazoles) has been elaborated based on the method proposed by Birkofer et al.The appropriate compounds are obtained in high yield and of analytical purity by the action of N-trimethylsilyl imidazole (triazole) on the corresponding acid chlorides.
- Dabkowski, W.,Michalski, J.,Skrzypczynski, Z.
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p. 321 - 326
(2007/10/02)
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