- Rh-mediated enantioselective synthesis, crystal structures, and photophysical/chiroptical properties of phenanthrenol-based [9]helicene-like molecules
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The enantioselective synthesis of phenanthrenol-based [9]-helicene-like molecules has been achieved via the rhodium-mediated intramolecular [2 + 2 + 2] cycloadditions of 3-phenanthrenol-linked triynes. Crystal structures and photophysical/chiroptical prop
- Yamano, Ryota,Hara, Jun,Murayama, Koichi,Sugiyama, Haruki,Teraoka, Kota,Uekusa, Hidehiro,Kawauchi, Susumu,Shibata, Yu,Tanaka, Ken
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- Palladium-catalyzed asymmetric synthesis of silicon-stereogenic dibenzosiloles via enantioselective C-H bond functionalization
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A Pd-catalyzed asymmetric synthesis of Si-stereogenic dibenzosiloles is developed through enantioselective C-H bond functionalization of prochiral 2-(arylsilyl)aryl triflates. High chemo- and enantioselectivities are achieved by employing a Josiphos-type ligand under mild conditions.
- Shintani, Ryo,Otomo, Haruka,Ota, Kensuke,Hayashi, Tamio
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p. 7305 - 7308
(2012/06/16)
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- Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists
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The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R1, R2, R3, R4, R4′, R5, R5′, and R12 are as described in the specification.
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Page/Page column 22
(2010/11/08)
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- Synthesis of concave 1,10-phenanthrolines by a combination of Suzuki coupling, ring closing metathesis and hydrogenation
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A wide variety of saturated and unsaturated concave 1,10-phenanthrolines 2 and 4 have been synthesized in good yields starting from dichloro-1,10- phenanthroline 14. In the three step synthesis, Suzuki couplings of bis-ortho-substituted boronic acids were
- Luening, Ulrich,Fahrenkrug, Frank
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p. 3119 - 3127
(2007/10/03)
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- SEROTONERGIC BENZOFURANS
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The present invention provides serotonergic benzofurans of Formula (I): where A, R, R, R, R, and R are as described in the specification.
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Page/Page column 16-17
(2010/02/04)
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- Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy
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Enantiomerically pure (3′R)- and (3′S)-3′,4′-dihydrospiro[piperidine-2,3′ (2′H)-benzopyran]s (R)-10 and (S)-10 were successfully synthesized according to the CN(R,S) methodology with the aim of serving as a pattern for the generation of related spirocyclic compounds. Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine (-)-2. One of them was selected and used for the preparation of amines (R)-17 and (S)-17 starting from (-)-2 and (+)-2, respectively. The enantiomeric purity of all final aminochroman derivatives was determinated by capillary electrophoresis using β-cyclodextrin as the chiral selector.
- Pave, Gregoire,Leger, Jean-Michel,Jarry, Christian,Viaud-Massuard, Marie-Claude,Guillaumet, Gerald
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p. 1401 - 1408
(2007/10/03)
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- BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS
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The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1, R2, R3, R4, R5, R5', R6, R6', R7, R7', R8, and R8' are as described in the specification.
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- The Regioselective Synthesis of Halophenols
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The reactions of borates and borinates with zirconocene complexes of substituted benzynes lead regioselectively to heterodimetallic compounds which were, without isolation, converted to the corresponding halophenols.
- Rege, Francis M. G. De,Buchwald, Stephen L.
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p. 4291 - 4296
(2007/10/02)
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- Regioselectivity in the Reactions of Methoxydehydrobenzenes with Furans. Part 1. Reactions of 3-Methoxydehydrobenzene and 3-(Methoxycarbonyl)dehydrobenzene with 2-Substituted Furans.
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The isomer ratios for the cycloadducts obtained for the reaction of 3-methoxydehydrobenzene, generated from 2-amino-6-methoxybenzoic acid by aprotic diazotization, or from 2-bromo-3-methoxyphenyl toluene-p-sulphonate by treatment with butyllithium, and fo
- Giles, Robin G. F.,Sargent, Melvyn V.,Sianipar, Hercules
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p. 1571 - 1579
(2007/10/02)
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