- Nematic phase formed by V-shaped molecules
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In the paper there are presented synthesis and properties of new banana-shaped molecules that are ester resorcinol derivatives. The compounds with lateral alkyl substituent at the 4-position of the resorcinol ring exhibit the liquid crystalline nematic phase. Some of the synthesised compounds are able to induce the anticlinic S*CA phase that proves their bent molecular shape.
- Szydlowska, Jadwiga,Matraszek, Joanna,Mieczkowski, Jozef,Gorecka, Ewa,Pociecha, Damian
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- Preparation method of 4-alkylresorcinol
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The invention discloses a preparation method of 4-alkyl resorcinol, and belongs to the field of organic synthetic chemistry. The method comprises the following steps: carrying out Claisen-Schmidt condensation reaction on 4-acetyl resorcinol and alkyl aldehyde to obtain an intermediate III, and carrying out catalytic hydrogenation reduction to obtain 4-alkyl resorcinol; the synthetic reaction route of the method is as follows: raw and auxiliary materials and reagents used in the method are low in toxicity, safe, low in price and easy to obtain; the yield is obviously improved, byproducts are reduced, and the production cost is reduced; high-toxicity and high-pollution reagents are prevented from being used in the reduction process, and environmental protection is achieved; different 4-alkyl resorcinol can be obtained by using alkyl aldehydes with different carbon atom numbers; the product prepared by the method is high in quality, and the method has a significant meaning for industrial production of 4-alkylresorcinol.
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Paragraph 0053-0055; 0059-0060
(2021/11/03)
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- Preparation method of 4-alkylresorcinol
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The invention discloses a preparation method of 4-alkylresorcinol. The preparation method comprises the steps: carrying out a reaction on resorcinol and alkyl acid to prepare acyl resorcinol, and then, catalyzing a hydrogenation reaction to obtain 4-alkylresorcinol. By using the method, the dosages of a catalyst and alkyl groups are controlled in an acylation process, so that the yield is remarkably increased, byproducts are reduced, and the production cost is reduced; and hydrogen reduction is adopted in a reduction process, and a high-toxicity and high-pollution zinc amalgam reducing agent is prevented from being used, so that the preparation method is green and environment-friendly; and the aftertreatment is simple, the prepared product is high in purity, the total yield of the two steps reaches up to 77%, and the preparation method has a remarkable significance for industrial production of 4-alkylresorcinol.
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Paragraph 0032; 0033; 0034; 0038
(2018/05/01)
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- Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists
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Compound 1 (IC50 = 35.2 ± 7.2 μM), a moderate FXR antagonist was discovered via high-throughput screening. Structure-activity relationship studies indicated that the shape and the lipophilicity of the substituents of the aromatic ring affect the activity dramatically, increasing the shape and the lipophilicity of the substituents of the aromatic ring enhances the potency of FXR antagonists. Especially, when the OH at C2 position of the aromatic ring was replaced by the OBn substituent (analog 2b), its activity could be improved to IC50 = 1.1 ± 0.1 μM. Besides, the length of the linker and the tetrazole structure are essential for retaining the activity.
- Liu, Peng,Xu, Xing,Chen, Lili,Ma, Lei,Shen, Xu,Hu, Lihong
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p. 1596 - 1607
(2014/03/21)
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- SKIN LIGHTENING COMPOSITIONS AND METHODS
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Skin lightening/even toning compositions are provided for reducing skin pigmentation of normal skin and for lightening hyper-pigmented skin said compositions comprising (i) highly purified hexylresorcinol which is substantially free or resorcinol, (ii) optionally, at least one other skin lightening agent, and (iii) a dermatologically acceptable carrier.
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Page/Page column 19-21
(2009/01/24)
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- Process for the synthesis of alkylresorcinols
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The invention provides a process for the production of 4-(C2-C16)alkylresorcinol. 4-(C2-C16)alkylresorcinol is produced by reacting resorcinol with a (C2-C16)alkyloic acid in the presence of a zinc chloride catalyst to produce an intermediate comprising a 4-(C2-C16)acylresorcinol and zinc ions. Then the intermediate is adjusted such that the zinc ion content is from about 0.1 to about 150 parts per million based on the weight of the intermediate to form an adjusted intermediate. Then the produced 4-(C2-C16)acylresorcinol is hydrogenated in the presence of the zinc ions and a base metal hydrogenation catalyst to produce a crude product comprising 4-(C2-C16)alkylresorcinol, which may thereafter be isolated.
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Page/Page column 3
(2008/06/13)
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- Antifungal Activity of 2,4-Dihydroxyacylophenones and Related Compounds
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The antifungal activity of 2,4-dihydroxyacylophenones and related compounds against Trichophyton spp. and other fungi were investigated to determine their structure-activity relationships.The activity of these compounds was found to be closely related to the length of the acyl and alkyl substituents attached to the 1,3-dihydroxybenzene moiety.In addition, differences in activity were observed depending on the position of the alkyl substituents and on the number of substituents attached to the 1,3-dihydroxybenzene moiety.Some compounds tested showed potent antifungal activity against Trichophyton spp. and other fungi that was more active than amphotericin B.
- Mizobuchi, Shigeyuki,Sato, Yuko
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p. 1327 - 1334
(2007/10/02)
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- N-alkylated cresylic acids via direct alkylation in a liquid phase
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A method for the production of n-alkylated cresylic acids such as n-hexyl resorcinol by direct alkylation of a cresylic acid such as resorcinol under liquid phase conditions.
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- Process for the manufacture of resorcinols
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Resorcinols are prepared by reacting 4-oxocarboxylic acid esters or δ-enollactones with a strong base in a glycol dialkyl ether as solvent and by subsequent dehydrogenating the acidified reaction product.
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