- METHOD FOR THE PREPARATION OF TRILOSTANE
-
The present invention relates to a method for the preparation of trilostane from (4α,5α,17β)-4,5-epoxyandrost-2-eno(2,3-d)isoxazol-17-o1 as a precursor compound, the method comprising the steps of a) dissolving the precursor compound in methanol; b) treating the precursor compound with a base to effect cleavage of the (2,3-d) isoxazole ring of the precursor compound; c) adding acid and water to the product of step b) to obtain a precipitate of Trilostanc; and d) isolating the precipitate of Trilostane.
- -
-
Page/Page column 7-8
(2008/06/13)
-