- Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
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Disclosed are novel amino acid derivatives of the formula: STR1 wherein X is H, amidino or STR2 Y is H, amino or STR3 Z is STR4 OR1 or a naturally occurring L-amino acid, bounded to the carbon atom at the α-amino position; R is alkyl, aryl or aralkyl; R1 and R2 are independently H, alkyl, aryl, aralkyl or allyl; m is 1 through 5; n is 0 through 4; and pharmaceutically acceptable salts thereof, that inhibit platelet aggregation and thrombus formation in mammalian blood.
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- Anti-thrombotic peptide and pseudopeptide derivatives
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Disclosed are novel peptide and pseudopeptide derivatives and phrmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood.
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