- The aldol type reaction catalyzed by arylmalonate decarboxylase - A decarboxylase can catalyze an entirely different reaction, aldol reaction
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The catalytic promiscuity of AMDase was demonstrated using a well-designed substrate based on the consideration of the reaction mechanism. As the reaction catalyzed by AMDase is supposed to proceed via an enolate intermediate, we expected that the enzyme
- Terao, Yosuke,Miyamoto, Kenji,Ohta, Hiromichi
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p. 420 - 421
(2007/10/03)
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- Lithium 2-(2-lithiomethylphenyl)ethanolate from isochroman: Easy preparation of substituted benzoxepines and functionalised arenes
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The reaction of isochroman (1) with an excess of lithium powder and a catalytic amount of DTBB (2.5 mol %) in THF at 20°C yields the title intermediate, which by reaction with different electrophiles (H2O, D2O, CO2 and carbonyl compounds) at temperatures ranging between -78 and 20°C yields, after hydrolysis, the corresponding products 3. Diols 3h-m, derived from benzaldehyde or ketones, give upon treatment with 85% phosphoric acid the corresponding benzoxepines 5h-m. In the other cases, Friedel-Crafts products resulting from a rearrangement of the first carbenium ion formed, are obtained.
- Almena, Juan,Foubelo, Francisco,Yus, Miguel
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p. 3365 - 3374
(2007/10/02)
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- Synthesis of Isomeric Methyl ε-Hydroxycarboxylates
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The synthesis of the three isomeric methyl ε-hydroxycarboxylates 3, 6 and 10a in good overall yields is described. - Key Words: Methyl ε-hydroxycarboxylates / Carboxylic acids, ε-hydroxy- / Phenylalkanoic acids, o-(hydroxyalkyl)-
- Arth, Christoph,Clemens, Martina,Meise, Werner
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p. 259 - 264
(2007/10/02)
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- Synthesis of Aromatic Annulated ε-Lactones
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The synthesis of three isomeric benzoxepinones 2, 7 and 8 by oxidation of the ω-diols 1 and 6 with silver carbonate on Celite is reported. Key Words: ε-Lactones / Oxidation of ω-diols with silver carbonate on Celite
- Meise, Werner,Arth, Christoph
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p. 163 - 166
(2007/10/02)
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