- Preparation method of 7-chlorin-(1-oxo ethyl) ethyl oenanthate
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The invention provides a preparation method of 7-chlorin-(1-oxo ethyl) ethyl oenanthate. 1-bromine-5-chloropentane of a structural formula III and ethyl acetoacetate of a structural formula IV are adopted as starting materials, under the existence of a polar solvent, an acid binding agent and a phase transfer catalyst, normal pressure heating is performed till the polar solvent is boiling, a reaction is performed for 6-8 h, and 7-chlorin-(1-oxo ethyl) ethyl oenanthate of a structural formula V is obtained. The phase transfer catalyst is selected from one or more of tetrabutylammonium bromide, tetrabutyl ammonium chloride, benzyl trimethyl ammonium chloride, benzyl trimethyl ammonium bromide, 18-crown-6, dibenzo-18-crown-6, polyethylene glycol-400, benzyltrimethylammonium chloride-400 and polyethylene glycol-600, and preferentially polyethylene glycol-400. The molar ratio of the phase transfer catalyst to ethyl acetoacetate is 0.2-1.0:1.0, and preferentially 0.2-0.3:1.0. The preparation method is short in reaction time, high in product yield and good in purity.
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Paragraph 0051; 0052
(2017/05/20)
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- METHOD FOR PURIFYING PYRUVIC ACID COMPOUNDS
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The present invention is directed to a method for purifying pyruvic acid compounds, which method comprises reacting a pyruvic acid compound of general formula (I): wherein R1is an optionally substituted lower alkyl group, a lower alkenyl group,
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