- Preparation method and application of novel spiro compound
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The invention discloses a preparation method and application of a novel spiro compound and belongs to the technical field of pesticide synthesis. Compared with the prior art, the preparation method and application have the advantage that the novel spiro c
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Paragraph 0026; 0027
(2018/05/01)
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- Triazole methyl ester linked spiro compound with antibacterial activity, and preparation method and application thereof
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The invention discloses a triazole methyl ester linked spiro compound with antibacterial activity, and a preparation method and application thereof, and belongs to the technical field of medicine synthesis. The key point of the technical scheme is as follows: the triazole methyl ester linked spiro compound with antibacterial activity has the following structure: (the formula is shown in the description). The invention also discloses a preparation method of the triazole methyl ester linked spiro compound with antibacterial activity. The reaction process is simple and practical in operation, theraw materials are cheap and easily available, the reaction efficiency is high, the repeatability is high, and a remarkable inhibition effect on escherichia coli is achieved.
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Paragraph 0027; 0028
(2018/05/16)
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- 3-(BIARYLOXY) PROPIONIC ACID DERIVATIVE
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A compound of the general formula (I): [wherein, R1 represents a halogen atom, or the like, R2 represents a hydrogen atom, or the like, R3 and R4, each independently, represent a hydrogen atom, a C1-4
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Page/Page column 39-40
(2012/07/14)
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- Imidazopyridine derivatives as PI3K inhibitors
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New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks)
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Page/Page column 43
(2012/11/13)
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- IMIDAZOPYRIDINE DERIVATIVES AS PI3K INHIBITORS
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New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).
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Page/Page column 97-98
(2012/11/13)
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- HETEROCYCLIC DERIVATIVES
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The present invention relates to heterocyclic derivatives, and more particularly, to novel heterocyclic derivatives useful for the preparation of medicaments for treating diseases related to uric acid.
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Page/Page column 52
(2011/02/25)
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- TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS
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Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents a group selected from H, CF3, and C1-6 alkyl (optionally substituted by C1-6 alkyloxy or triazolyl); R2/
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Page/Page column 45
(2010/11/24)
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- Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
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This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
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- Azaoxindole derivatives
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This invention relates to novel 4-, 5-, 6-, and 7-azaoxindole derivatives. The compounds are anti-inflammatory and analgesic agents and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. They are useful in the treatment of chronic inflammatory diseases, allergy, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosis.
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- Synthesis of substituted azaoxindoles for the preparation of aza-tenidap analogs
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The preparation of a set of eight azaoxindoles bearing substituents on the aromatic nucleus is outlined. These compounds were required for the preparation of aza-analogs of the anti-inflammatory oxindole tenidap. Two methods of synthesis were used, the fi
- Robinson, Ralph P.,Donahue, Kathleen M.,Son, Paul S.,Wagy, Steven D.
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p. 287 - 293
(2007/10/03)
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- Azaoxindole derivatives
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This invention relates to novel 4-, 5-, 6-, and 7-azaoxindole derivatives. The compounds are anti-inflammatory and analgesic agents and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. They are useful in the treatment of chronic inflammatory diseases, allergy, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosis.
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