- 4-Aryl-2-Imino-1,3-Dithiolanes from the Room Temperature Coupling of Sodium Dithiocarbamates with Sulfonium Salts
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A series of 4-aryl-2-imino-1,3-dithiolanes was synthesized by means of a straightforward strategy starting from readily available precursors: reactions of dithiocarbamates and arylsulfonium salts, at room temperature in water/CH2Cl2 as biphasic medium, afforded the five-membered cyclic products in good yields. The reaction mechanism was investigated by DFT calculations.
- Bresciani, Giulio,Marchetti, Fabio,Ciancaleoni, Gianluca,Pampaloni, Guido
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- Method for synthesizing metham in one step
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The invention discloses a method for synthesizing a soil fumigant metham in one step. The method comprises the following steps: stirring and mixing water, a monomethylamine aqueous solution and a sodium hydroxide aqueous solution, dropwise adding carbon disulfide, continuously stirring and reacting to obtain a finished product of metham with the appearance of yellow to red brown, wherein the finished product is used for treating soil fumigation and disinfection and killing root-knot nematodes, harmful bacteria and soil insects and removing weeds. The whole synthesis method has the advantages of high production efficiency, high product content, high operation safety, good storage stability and environmental friendliness.
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Paragraph 0021-0022; 0024
(2020/11/12)
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- Dithiolane-Isocyanate Imminium Methylides: A Rapid Stereoselective Entry into γ-Lactams
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Methods have been developed for the generation and trapping of dithiolane-isocyanate imminium methylides which are a new type of azomethine methylide-derived 1,3-dipole.These species add efficiently and stereoselectively to electron deficient olefins yielding novel dithiolane-protected γ-lactams which can be efficiently deprotected to yield the corresponding lactam systems.
- Fishwick, Colin W. G.,Foster, Richard J.,Carr, Robin E.
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p. 9409 - 9412
(2007/10/02)
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- Characterization of protein adducts produced by N-methyldithiocarbamate and N-methyldithiocarbamate esters
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The toxicity of N-methyldithiocarbamate may be mediated through decomposition to more biologically active compounds. Two principal products, CS2 and methyl isothiocyanate, have the potential to interact covalently with macromolecules in biological systems. In this investigation the ability of N-methyldithiocarbamate to generate methyl isothiocyanate and CS2 under physiological conditions resulting in acylation and covalent cross-linking of proteins was examined using 13C NMR and GC/MS. Two N-methyldithiocarbamate esters, S-methyl N-methyldithiocarbamate and (N-acetyl-S- methylthiocarbamoyl)cysteine, were also investigated to evaluate the acylating ability of sulfhydryl conjugates of N-methyldithiocarbamate. The predominant and most stable adduct produced by the free dithiocarbamate and its S-substituted esters was methylthiourea on ε-lysyl and N-terminal α- amino groups. Derivatization on N-terminal amino groups progressed more rapidly for the dithiocarbamate than for its mercapturate. Methylurea protein adducts were also produced by the dithiocarbamate and its esters, suggesting production of methyl isocyanate in the decomposition of N- methyldithiocarbamate. Covalent cross-linking of β-lactoglobulin by N- methyldithiocarbamate resulting from its decomposition to CS2 was observed using denaturing polyacrylamide gel electrophoresis. These results demonstrate the ability of a monoalkyldithiocarbamate to acylate protein amino groups and effect covalent cross-linking. These processes represent molecular mechanisms that may contribute to the toxicity of this class of compounds.
- Valentine,Amarnath,Amarnath,Graham
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p. 254 - 261
(2007/10/03)
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