cas 137-44-0, 1,3,5PYRAZOLONE | Articles data

A series of 3-aryl-4-(arylhydrazono)-1H-pyrazol-5-one inhibitors of GSK3β was developed from a low molecular weight, highly ligand efficient screening hit 1. Hit-to-lead optimization led to a number of highly potent inhibitors, while maintaining the high ligand efficiency of the screening hit.

A method for preparing 2-pyrazolin-5-ones from 1,2,4-oxadiazoles is described. The method comprises forming a liquid reaction system of a base catalyst and a 1,2,4-oxadiazole in an organic liquid reaction medium and heating the reaction system to a temperature sufficient to cause the 1,2,4-oxadiazole to be rearranged to a 2-pyrazolin-5-one.

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Chemical Properties

Melting Point: 268℃

Boiling Point: 143-144℃ (0.3 Torr)

Density: 1.44 g/cm³

Storage Temp.:Sealed in dry,Room Temperature

Refractive Index: 1.63

PKA: 13.06±0.20(Predicted)

PSA: 41.46000

LogP: -0.74350

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137-44-0

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Chemical Properties

Melting Point: 268℃

Boiling Point: 143-144℃ (0.3 Torr)

Density: 1.44 g/cm3

Storage Temp.:Sealed in dry,Room Temperature

Refractive Index: 1.63

PKA: 13.06±0.20(Predicted)

PSA: 41.46000

LogP: -0.74350

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Density: 1.44 g/cm³