Synthesis and Isomerization Studies of 2-Alkenylthiopyrimidines and 2-Alkynylthiopyrimidines and Their S-Oxides
Selective oxidations for the preparation of either sulfoxides or sulfones of 2-allyl, 2-propadienyl- and 2-propargylthio-5-chloropyrimidines are described.The 2-propargylsulfone as well as its sulfide is easily isomerized to the isomeric allenes.The unsaturated sulfides are conveniently prepared in a condensation reaction between 1,3-bis-N,N-dimethylamino-2-chlorotrimethinium perchlorate and the respective isothiourea.
Benneche, Tore,Undheim, Kjell
p. 115 - 120
(2007/10/02)
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