- SPIROINDOLINONE DERIVATIVES
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The present invention relates to spiroindolinone derivatives of the formula and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7 and R8, are as herein described.
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Page/Page column 80
(2008/06/13)
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- Process for the manufacture of 2-alkoxymethylacrolein
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There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted amine. There is also provided a process for the manufacture of 3-alkoxymethylquinolines from 2-alkoxymethylacrolein.
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- Proccess for the manufacture of 2-alkoxymethylacrolein
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There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted amine.
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- Facile Access to 2-Alkylidene 3-Oxy Propanals and Propionic Acids from Conjugated Enals
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Conjugated enals or their methyl acetals react with benzeneselenyl chloride in the presence of oxygen nucleophile to give Michael-type adducts.The latter are oxidized into 2-alkylidene 3-oxy propanals and propionic acids.
- Huot, Jean-Francois,Outurquin, Francis,Paulmier, Claude
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p. 1599 - 1602
(2007/10/02)
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