Synthesis and evaluation of a series of 3,5-disubstituted benzisoxazole- 4,7-diones. Potent radiosensitizers in vitro
A series of 3,5-disubstituted-2,1-benzisoxazole-4,7-diones was synthesized and evaluated as radiosensitizers both in vitro and in vivo. These compounds were designed as non-nitro electron-affinic agents in an effort to alleviate some of the toxicities see