- Dioxolobenzothienoquinolin-6(5H)-ones
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The reaction of 3,4-methylenedioxycinnamic acid (1) with thionyl chloride resulted in the formation of 7-chlorothieno-1,3-benzodioxole-6-carbonyl chloride (2) and cinnamoyl chloride (3).Subsequent reaction of the former with p-substituted anilines
- Gakhar, H. K.,Kaur, R.,Gupta, S. B.
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- New fibrinolytic agents: Benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation
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The synthesis and activity of novel benzothiophene derivatives are described. In the t-Pa-induced fibrin clot lysis assay, several compounds inhibit the formation of the tPa-PAI-1 complex with submicromolar IC50. This class of compounds potentially represents a new generation of antithrombotic-fibrinolytic agents.
- De Nanteuil, Guillaume,Lila-Ambroise, Christine,Rupin, Alain,Vallez, Marie-Odile,Verbeuren, Tony J.
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p. 1705 - 1708
(2007/10/03)
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- Benzothiophene, benzofuran and indole compounds
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A compound selected from those of formula (I): wherein: X represents oxygen, sulphur, or NR3wherein R3is as defined in the description, Y represents oxygen, sulphur, NR3, or may represent single bond in certain cases, T re
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