Synthesis and Properties of a Maleimide Fluorescent Thiol Reagent Derived from a Naphthopyranone
N-(2-Carbomethoxy-9-methoxy-3-oxo-3H-naphthopyran-10-yl)maleimide 2 was designed and synthesized as a new maleimide fluorescent thiol reagent.The optical properties of 2 were investigated with an without the addition of glutathione, GSH.We have found 2 is twice as sensitive as DACM and is of comparable sensitivity to CPM for detection of thiols.The emission maximum for the GSH adduct of 2 is 513 nm which is at longer wavelength than the GSH adducts of both DACM and CPM.
Yang, Jun-Rui,Langmuir, Margaret E.
p. 1177 - 1180
(2007/10/02)
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