A synthesis of (-)-alantrypinone is described. The synthesis features the use of [Me3AlSPh]Li as a promoter of a 4-iminobenzoxazine to 4- quinazolinone rearrangement and as a reagent for the deprotection of an Fmoc- protected amino acid derivat
Mild and highly chemoselective oxidation of thioethers mediated by Sc(OTf)3
(Matrix presented) Catalytic Sc(OTf)3 greatly increases the efficiency of hydrogen peroxide mediated monooxidation of alkyl-aryl sulfides and methyl cysteine containing peptides. The method is high yielding, compatible with many widely used protecting groups, suitable for solid-phase applications and proceeds with minimum over-oxidation.
Matteucci, Mizio,Bhalay, Gurdip,Bradley, Mark
p. 235 - 237
(2007/10/03)
Synthesis of ent-alantrypinone
This paper presents a synthesis of ent-alantrypinone (ent-6), the enantiomer of a natural product produced by the fungus Penicillium thymicola. The synthesis revolves around the Li[Me3AlSPh]-promoted isomerization of iminobenzoxazine 33 to quin
Hart,Magomedov
p. 5892 - 5899
(2007/10/03)
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