Fast synthesis of complex enantiopure heterocyclic scaffolds by a tandem sequence of simple transformations on α-hydroxyaldehydes
Two tandems are faster than one! Properly sequenced reactions initiated by the Petasis aminoalcohol synthesis from boronic acids, diallylamine, and α-hydroxyaldehydes, including free aldoses, leads to rapid construction of complex enantiopure structures (see scheme). Copyright
Cannillo, Alexandre,Norsikian, Stephanie,Retailleau, Pascal,Dau, Marie-Elise Tran Huu,Iorga, Bogdan I.,Beau, Jean-Marie
Palladium catalysed tandem cyclisation-anion capture. Part 8: Cascade hydrostannylation-cyclisation-anion capture and cascade hydroboration-cyclisation-anion capture on solid phase
Up to four bonds and five stereocentres are created, in five component processes (five point diversity), utilising resin bound aryl iodides by hydroboration or hydrostannylation of alkynes, followed by cyclisation-anion capture involving Suzuki or Stille reactions. Three small libraries were prepared to validate the chemistry.
Grigg, Ronald,MacLachlan, William S,MacPherson, David T,Sridharan, Visuvanathar,Suganthan, Selvaratnam
p. 10335 - 10345
(2007/10/03)
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