- Novel, malonyl-derived edta analogues
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Reaction of malonyl dichloride and benzylmalonyl dichloride with iminodiacetate esters has provided access to several, novel EDTA analogues.
- Hagemann, Justin P.,Kaye, Perry T.
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- Deferoxamine derivative compound with bone affinity, preparation method and application thereof
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The invention develops a deferoxamine derivative with bone affinity, a preparation method and application thereof. More specifically, the invention provides a compound with a structure shown as formula (1) and its pharmaceutically acceptable salt, ester, amide, acyl halide, hydrate or solvate. The invention also provides a preparation method of the compound shown as formula (1) and application thereof in preparation of drugs for treatment of osteoporosis, osteonecrosis, delayed union or nonunion and bone defect. (formula I).
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Paragraph 0081; 0082
(2017/07/21)
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