Lipase-catalyzed enantioselective synthesis of optically active mephrobarbital, hexobarbital and febarbamate
Chiral 5,5-disubstituted N-acyloxymethylbarbiturates have been obtained in 40-99% optical yields by lipase-catalyzed hydrolyses of 5,5-disubstituted N,N'-bisacyloxymethylbarbiturates in H2O-saturated diisopropyl ether. These chiral barbiturates
Murata,Uchida,Achiwa
p. 2605 - 2609
(2007/10/02)
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