Synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives
Full details of the synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives are detailed based on an intramolecular nucleophilic aromatic substitution reaction for formation of the key biaryl ether with 14-membered ring macrocyclization. Their comparison with prior samples and the documentation of a facile C9 epimerization within the natural 9S series are described.
Boger, Dale L.,Zhou, Jiacheng,Borzilleri, Robert M.,Nukui, Seiji,Castle, Steven L.
p. 2054 - 2069
(2007/10/03)
Alternative synthesis of the cycloisodityrosine subunit of deoxybouvardin, RA-VII, and related agents: Reassignment of the stereochemistry of prior intermediates
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Boger, Dale L.,Zhou, Jiacheng
p. 3938 - 3939
(2007/10/03)
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